MED18_CAEEL
ID MED18_CAEEL Reviewed; 232 AA.
AC Q966M5;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE AltName: Full=Mediator complex subunit 18;
GN Name=mdt-18; ORFNames=C55B7.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080958; CCD68096.1; -; Genomic_DNA.
DR RefSeq; NP_491869.1; NM_059468.4.
DR AlphaFoldDB; Q966M5; -.
DR SMR; Q966M5; -.
DR BioGRID; 48653; 2.
DR DIP; DIP-26593N; -.
DR IntAct; Q966M5; 2.
DR STRING; 6239.C55B7.9.1; -.
DR EPD; Q966M5; -.
DR PaxDb; Q966M5; -.
DR PeptideAtlas; Q966M5; -.
DR PRIDE; Q966M5; -.
DR EnsemblMetazoa; C55B7.9a.1; C55B7.9a.1; WBGene00007018.
DR EnsemblMetazoa; C55B7.9a.2; C55B7.9a.2; WBGene00007018.
DR EnsemblMetazoa; C55B7.9a.3; C55B7.9a.3; WBGene00007018.
DR GeneID; 183844; -.
DR KEGG; cel:CELE_C55B7.9; -.
DR UCSC; C55B7.9.1; c. elegans.
DR CTD; 183844; -.
DR WormBase; C55B7.9a; CE09020; WBGene00007018; mdt-18.
DR eggNOG; KOG3264; Eukaryota.
DR GeneTree; ENSGT00390000003312; -.
DR HOGENOM; CLU_084570_0_0_1; -.
DR InParanoid; Q966M5; -.
DR OMA; LPWQLRY; -.
DR OrthoDB; 1140930at2759; -.
DR PhylomeDB; Q966M5; -.
DR PRO; PR:Q966M5; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00007018; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q966M5; baseline and differential.
DR GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR InterPro; IPR019095; Mediator_Med18.
DR PANTHER; PTHR13321; PTHR13321; 1.
DR Pfam; PF09637; Med18; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..232
FT /note="Mediator of RNA polymerase II transcription subunit
FT 18"
FT /id="PRO_0000304751"
SQ SEQUENCE 232 AA; 26626 MW; BF77638035A5E3DD CRC64;
MDNLVDIDED GTQEKLSVNS TPYQTQECVL YGSIFAKNVP DLERRLAGLC DPGCEEFFEH
EMSFSLRSSG IMDIKTDIKL RRRFRTEHRI QNYWQLKYIG VPEPDQKCPT IVRKEISSLV
HSQDMMTYAK SLGLRMDYEY MTQGKLWTKG NIKILHSILT STSRAGTYDS NSIKSVSDSA
LVEISISLPE SAEYMPAAKS LRDFADQLMP LVNMEKVDYW KKMFPAQAAP RR
