ID   MED18_CANAL             Reviewed;         351 AA.
AC   Q59X40; A0A1D8PIB3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=SRB5; Synonyms=MED18; OrderedLocusNames=CAALFM_C209300WA;
GN   ORFNames=CaO19.11572, CaO19.4091;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017624; AOW27913.1; -; Genomic_DNA.
DR   RefSeq; XP_714262.1; XM_709169.1.
DR   AlphaFoldDB; Q59X40; -.
DR   BioGRID; 1227197; 3.
DR   STRING; 237561.Q59X40; -.
DR   PRIDE; Q59X40; -.
DR   GeneID; 3644103; -.
DR   KEGG; cal:CAALFM_C209300WA; -.
DR   CGD; CAL0000197175; MED18.
DR   VEuPathDB; FungiDB:C2_09300W_A; -.
DR   eggNOG; ENOG502S41C; Eukaryota.
DR   HOGENOM; CLU_058255_0_0_1; -.
DR   InParanoid; Q59X40; -.
DR   OMA; PGKVNQI; -.
DR   OrthoDB; 1167687at2759; -.
DR   PRO; PR:Q59X40; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..351
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304757"
FT   REGION          153..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  40184 MW;  B41F1E5763C67E37 CRC64;
     MVHQLSLVSS IPHNKYLQTI STLQALTGLI QPESISTYTL LAKPSYAFKP KFEPGKVNQI
     EQYYMRCITT WNSDKQGDDE KVEKGFDISE PFINKESNIV VRKLFTEEDS VERVWTLQVS
     DIPVAGKNQG CCQQQIYEST LVHTHTAIEI KVGNGDPIDI DTNNDKQGDN NTDKPKQEHD
     GKLPEAIDED IIKNGDEKKT THDDNDSDIM EIDEPNPETQ TLPQSLSNGV SQRTTRKDSF
     LIFLSDLGYE VINQYWQKGV RFFYGDIIIE IYKIFIRDES SQADSNEGIK LKLLDDSNQF
     QIKAYININK STEIDSINSG VKELIKLQEF LKNLFVLEIP DRMFMDSRIK Q