ID   MED18_DANRE             Reviewed;         208 AA.
AC   Q7T3H7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=med18;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; BC053113; AAH53113.1; -; mRNA.
DR   RefSeq; NP_956629.1; NM_200335.1.
DR   AlphaFoldDB; Q7T3H7; -.
DR   SMR; Q7T3H7; -.
DR   STRING; 7955.ENSDARP00000060446; -.
DR   PaxDb; Q7T3H7; -.
DR   Ensembl; ENSDART00000060447; ENSDARP00000060446; ENSDARG00000041237.
DR   GeneID; 393306; -.
DR   KEGG; dre:393306; -.
DR   CTD; 54797; -.
DR   ZFIN; ZDB-GENE-040426-1276; med18.
DR   eggNOG; KOG3264; Eukaryota.
DR   GeneTree; ENSGT00390000003312; -.
DR   HOGENOM; CLU_084570_0_0_1; -.
DR   InParanoid; Q7T3H7; -.
DR   OMA; PTSPWHL; -.
DR   OrthoDB; 1140930at2759; -.
DR   PhylomeDB; Q7T3H7; -.
DR   TreeFam; TF313246; -.
DR   PRO; PR:Q7T3H7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000041237; Expressed in mature ovarian follicle and 24 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 2.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304744"
SQ   SEQUENCE   208 AA;  23289 MW;  505F748E8A8836E5 CRC64;
     MEAPPVTVMP VTGGTINMME YLLQGSVLDQ SLESLLHRLR GLCDNMEPES FADHELVYLL
     KGQQGNPFIL RARRSLLDPS VPWHLRYLGQ PEVGDKSRHA LVRNCVDVAA SHSLPDFLNE
     MGFRMDHEFV AKGQVFRKGV MKVVVSKLSR VLVPGNTDNT EPLSLSYLVE LSVLAPAGQD
     TVSEDMRSFA EQLKPLVHLE KIDPKRLM