ID   MED18_DEBHA             Reviewed;         341 AA.
AC   Q6BXL9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=SRB5; Synonyms=MED18; OrderedLocusNames=DEHA2B01914g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382134; CAG85036.1; -; Genomic_DNA.
DR   RefSeq; XP_457050.1; XM_457050.1.
DR   AlphaFoldDB; Q6BXL9; -.
DR   SMR; Q6BXL9; -.
DR   STRING; 4959.XP_457050.1; -.
DR   EnsemblFungi; CAG85036; CAG85036; DEHA2B01914g.
DR   GeneID; 2913032; -.
DR   KEGG; dha:DEHA2B01914g; -.
DR   VEuPathDB; FungiDB:DEHA2B01914g; -.
DR   eggNOG; ENOG502S41C; Eukaryota.
DR   HOGENOM; CLU_058255_0_0_1; -.
DR   InParanoid; Q6BXL9; -.
DR   OMA; PGKVNQI; -.
DR   OrthoDB; 1167687at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304760"
FT   REGION          139..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  39001 MW;  231E975A7CE4B0C7 CRC64;
     MVHQLSLVSM VSHSNYVQTI STLQALTGLL TPQPISTYTL VTKPHDVFKP KFEPGKVNQI
     EQFYMRCVTT WNDETGNKFD LASPVLENDT DILVNRLFLG VDDRRNWTMQ ISDIPIAGKN
     QACSAQTIYE STLVHHHTKV MDKEKVQSDV SNESNMDIDD KDEDKKENIK KEESGEEVKG
     SGEEVKGSGE EVKGSGEEAK KSGEEAKEHS EGNASQTVKE LVVLNRRDSF LQFLEDLGYD
     VINQFWMKGV RFFHGDIVIE IFKVFVRDDE KDAEKDKIRL KLLDPSNTFQ IRTYINVPKS
     TDVELINQGT KDLLKLQEFL KNLIKLEIPD RMFMDSRVTY K