ID   MED18_DICDI             Reviewed;         251 AA.
AC   Q54MR3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Putative mediator complex subunit 18;
GN   Name=med18; ORFNames=DDB_G0285713;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=18515835; DOI=10.1093/nar/gkn349;
RA   Bourbon H.-M.;
RT   "Comparative genomics supports a deep evolutionary origin for the large,
RT   four-module transcriptional mediator complex.";
RL   Nucleic Acids Res. 36:3993-4008(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64694.1; -; Genomic_DNA.
DR   RefSeq; XP_638230.1; XM_633138.1.
DR   AlphaFoldDB; Q54MR3; -.
DR   SMR; Q54MR3; -.
DR   STRING; 44689.DDB0266918; -.
DR   PaxDb; Q54MR3; -.
DR   EnsemblProtists; EAL64694; EAL64694; DDB_G0285713.
DR   GeneID; 8625278; -.
DR   KEGG; ddi:DDB_G0285713; -.
DR   dictyBase; DDB_G0285713; med18.
DR   eggNOG; KOG3264; Eukaryota.
DR   HOGENOM; CLU_1108740_0_0_1; -.
DR   InParanoid; Q54MR3; -.
DR   OMA; YAEYLYP; -.
DR   PhylomeDB; Q54MR3; -.
DR   PRO; PR:Q54MR3; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 18"
FT                   /id="PRO_0000388656"
SQ   SEQUENCE   251 AA;  28507 MW;  FD4DF98F5F710BC0 CRC64;
     MFQQNKHHQQ QQQQQQQQGV VQSGVASATV NNPSESIVAG NIYECSLHGI LSTPSSTFIQ
     RAKGMMRCEH PVSYKEMVFK STVQSAGPSW AEGSILPSEI HVRYEKNTVY VRYVGVPQIK
     DNINAMIRNV VDIKSSETFF IYLENLGYVK DYEYFVDGYQ YSTYNLSLFL VNHRRVLNDG
     TKGELLNKHS MVELQCLSGE EGFVAAAEYL NTYAEYLYPF VELIKFDHRL LTAENSNTPT
     TNVNVVGGYN R