MED18_PICST
ID MED18_PICST Reviewed; 348 AA.
AC A3LU54;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE AltName: Full=Mediator complex subunit 18;
GN Name=SRB5; Synonyms=MED18; ORFNames=PICST_83532;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC {ECO:0000305}.
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DR EMBL; CP000498; ABN66182.2; -; Genomic_DNA.
DR RefSeq; XP_001384211.2; XM_001384174.1.
DR AlphaFoldDB; A3LU54; -.
DR STRING; 4924.XP_001384211.2; -.
DR PRIDE; A3LU54; -.
DR EnsemblFungi; ABN66182; ABN66182; PICST_83532.
DR GeneID; 4838780; -.
DR KEGG; pic:PICST_83532; -.
DR eggNOG; ENOG502S41C; Eukaryota.
DR HOGENOM; CLU_058255_0_0_1; -.
DR InParanoid; A3LU54; -.
DR OMA; PGKVNQI; -.
DR OrthoDB; 1167687at2759; -.
DR Proteomes; UP000002258; Chromosome 4.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019095; Mediator_Med18.
DR PANTHER; PTHR13321; PTHR13321; 1.
DR Pfam; PF09637; Med18; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..348
FT /note="Mediator of RNA polymerase II transcription subunit
FT 18"
FT /id="PRO_0000304764"
FT REGION 152..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..223
FT /evidence="ECO:0000255"
SQ SEQUENCE 348 AA; 40076 MW; 7CF3072425CA588E CRC64;
MVHQLSLVSS IAHGSYVQTV STLQAFTGML SPQPIATYTL LTKPHEVFKP KFEPGKVNQI
EQYYMKCITT WSDGSEFDLA SAVIKENGSS NVFSGRLFHA EDESVQRIWT LQISDIPIAG
KNQACSAQTI YESTLIHTHT NVKSEENKID AMDVDLEHKD KSDVKGDTKE KEEDKKEEDK
KEEDKKEEDK KEEDKKEEDK KEEEKVEKKN DEVKHSEVNL EDGAETGSGH KDSFLQFLED
LGYETISQYW IKGIRFFHGD IVIEIFKVLV RDDEVTEPKE EGKIALKLLD ESNTFQIRTY
INIAKSTDID LINQGTKELL RLQEFLKNLF KLEIPDRMFM DSRVQVRK
