ID   MED18_XENLA             Reviewed;         208 AA.
AC   Q6DD39;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=med18;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; BC077790; AAH77790.1; -; mRNA.
DR   RefSeq; NP_001086933.1; NM_001093464.1.
DR   AlphaFoldDB; Q6DD39; -.
DR   SMR; Q6DD39; -.
DR   MaxQB; Q6DD39; -.
DR   DNASU; 446768; -.
DR   GeneID; 446768; -.
DR   KEGG; xla:446768; -.
DR   CTD; 446768; -.
DR   Xenbase; XB-GENE-6255351; med18.S.
DR   OMA; PTSPWHL; -.
DR   OrthoDB; 1140930at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 446768; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 2.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304745"
SQ   SEQUENCE   208 AA;  23210 MW;  2E9891252CCEFA28 CRC64;
     MEAPPVTTMP VSGGTINMME YLLQGSILDQ GLESLLHRLR GLCDNMEPET FADHESVYLL
     KGQQASPFVL RARRPLDRPG APWHLRYLGQ PEAGDRSRHT LVRNCVDIAT SDVLPEFLQE
     MGFRMDHEFV ARGHLFRKGV MKVAVYKVFR VLVSGAAEGA EPLSLSYLVE LSAVAPAGQD
     NIADEVRGFA EQLRPLVQLE KIDPKRVM