ID   MED18_XENTR             Reviewed;         208 AA.
AC   Q28GE1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=med18; ORFNames=TEgg017e01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; CR761425; CAJ82247.1; -; mRNA.
DR   RefSeq; NP_001017086.1; NM_001017086.2.
DR   RefSeq; XP_017946763.1; XM_018091274.1.
DR   AlphaFoldDB; Q28GE1; -.
DR   SMR; Q28GE1; -.
DR   STRING; 8364.ENSXETP00000062949; -.
DR   PaxDb; Q28GE1; -.
DR   Ensembl; ENSXETT00000044632; ENSXETP00000044632; ENSXETG00000020654.
DR   GeneID; 549840; -.
DR   KEGG; xtr:549840; -.
DR   CTD; 54797; -.
DR   Xenbase; XB-GENE-1002158; med18.
DR   eggNOG; KOG3264; Eukaryota.
DR   HOGENOM; CLU_084570_0_0_1; -.
DR   InParanoid; Q28GE1; -.
DR   OrthoDB; 1140930at2759; -.
DR   PhylomeDB; Q28GE1; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020654; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 2.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..208
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304746"
SQ   SEQUENCE   208 AA;  23208 MW;  2E9F63252CCEE5C8 CRC64;
     MEAPPVTTMP VSGGTINMME YLLQGSILDQ GLESLLHRLR GLCDNMEPET FADHESVYLL
     KGQQASPFVL RARRPLDRPG APWHLRYLGQ PEAGDRSRHT LVRNCVDIAT SDVLPEFLQE
     MGFRMDHEFV ARGHLFRKGV MKVAVYKVFR VLVAGAAEGA EPLSLSYLVE LSAVAPAGQD
     NIADEVRGFA EQLRPLVQLE KIDPKRLM