ID   MED18_YARLI             Reviewed;         231 AA.
AC   Q6CDK1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 18;
DE   AltName: Full=Mediator complex subunit 18;
GN   Name=SRB5; Synonyms=MED18; OrderedLocusNames=YALI0B23320g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 18 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382128; CAG83514.1; -; Genomic_DNA.
DR   RefSeq; XP_501261.1; XM_501261.1.
DR   AlphaFoldDB; Q6CDK1; -.
DR   SMR; Q6CDK1; -.
DR   STRING; 4952.CAG83514; -.
DR   EnsemblFungi; CAG83514; CAG83514; YALI0_B23320g.
DR   GeneID; 2906623; -.
DR   KEGG; yli:YALI0B23320g; -.
DR   VEuPathDB; FungiDB:YALI0_B23320g; -.
DR   HOGENOM; CLU_1200630_0_0_1; -.
DR   InParanoid; Q6CDK1; -.
DR   OMA; DRKSMDS; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0070847; C:core mediator complex; IBA:GO_Central.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR019095; Mediator_Med18.
DR   PANTHER; PTHR13321; PTHR13321; 1.
DR   Pfam; PF09637; Med18; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..231
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   18"
FT                   /id="PRO_0000304765"
FT   COILED          191..218
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  26750 MW;  DBA2632EBF0A3F10 CRC64;
     MQQISLYAKI SNSQLKICLH ALASLTGMDP ITILQHTMVW APAQKYTPKI LPGQGGQLDQ
     YRIHVTNDNK NEDKEKIISY VQSKDSKEDI HNLANRQWHF QIMEMPEAGK QKTTSQSISS
     WSVKKGDSFQ FLQSLAYKFQ YEYWQKGFQF VYGNAVIQLT RIHILDQTTK NIKLLDPSKQ
     WLVKVYIDVG HLTDIEALNK AVKELEKVKT ELHGLMNLEI PDRNAFDTRI R