ID   MED19_AEDAE             Reviewed;         253 AA.
AC   Q174D3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=MED19; ORFNames=AAEL006934;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477413; EAT41431.1; -; Genomic_DNA.
DR   RefSeq; XP_001652347.1; XM_001652297.1.
DR   AlphaFoldDB; Q174D3; -.
DR   STRING; 7159.AAEL006934-PA; -.
DR   GeneID; 5568522; -.
DR   KEGG; aag:5568522; -.
DR   VEuPathDB; VectorBase:AAEL006934; -.
DR   eggNOG; KOG4043; Eukaryota.
DR   HOGENOM; CLU_098332_1_0_1; -.
DR   InParanoid; Q174D3; -.
DR   OMA; KQKRHDD; -.
DR   OrthoDB; 1484317at2759; -.
DR   PhylomeDB; Q174D3; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019403; Mediator_Med19_met.
DR   PANTHER; PTHR22536; PTHR22536; 1.
DR   Pfam; PF10278; Med19; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..253
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304772"
FT   REGION          18..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..184
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..235
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28087 MW;  192384764A591332 CRC64;
     MFNNYGNVMM TDQFRKVEQY SPKSSPRAGG AGGRSPVVAR QDSSGTLKTT IQLGKNPSIV
     HSGPFYLMKE PPGEGELTGA TNLMAHYGLE HSYSKFSGKK VKEQLSSFLP NLPGVIDGPG
     HLDNSSLRSV IEKPPIGGKD LLPLTSVQLA GFRLHPGPLP EQYKHLKSVP TRKHKNKHKK
     HKYKEGVAPL SEQSALEASG LDTHEKKHKK QKRHEDDKER KKRKKEKKRK KQRHSPEHPG
     SGAASMPPQT QVF