MED19_CAEEL
ID MED19_CAEEL Reviewed; 199 AA.
AC Q9N4F2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE AltName: Full=Mediator complex subunit 19;
GN Name=mdt-19; ORFNames=Y71H2B.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC {ECO:0000305}.
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DR EMBL; FO081557; CCD72411.1; -; Genomic_DNA.
DR RefSeq; NP_497587.1; NM_065186.3.
DR AlphaFoldDB; Q9N4F2; -.
DR BioGRID; 40626; 4.
DR DIP; DIP-24361N; -.
DR IntAct; Q9N4F2; 3.
DR STRING; 6239.Y71H2B.6; -.
DR EPD; Q9N4F2; -.
DR PaxDb; Q9N4F2; -.
DR PeptideAtlas; Q9N4F2; -.
DR EnsemblMetazoa; Y71H2B.6.1; Y71H2B.6.1; WBGene00007019.
DR EnsemblMetazoa; Y71H2B.6.2; Y71H2B.6.2; WBGene00007019.
DR GeneID; 175378; -.
DR KEGG; cel:CELE_Y71H2B.6; -.
DR UCSC; Y71H2B.6; c. elegans.
DR CTD; 175378; -.
DR WormBase; Y71H2B.6; CE22945; WBGene00007019; mdt-19.
DR eggNOG; KOG4043; Eukaryota.
DR GeneTree; ENSGT00390000001774; -.
DR HOGENOM; CLU_098332_1_0_1; -.
DR InParanoid; Q9N4F2; -.
DR OMA; KQKRHDD; -.
DR OrthoDB; 1484317at2759; -.
DR PhylomeDB; Q9N4F2; -.
DR PRO; PR:Q9N4F2; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007019; Expressed in embryo and 4 other tissues.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR019403; Mediator_Med19_met.
DR PANTHER; PTHR22536; PTHR22536; 1.
DR Pfam; PF10278; Med19; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..199
FT /note="Mediator of RNA polymerase II transcription subunit
FT 19"
FT /id="PRO_0000304774"
FT REGION 155..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 199 AA; 22798 MW; A0A4DC7770800C06 CRC64;
MNEPSACSGP PVKSKSSKNE PFYTLKALLP PYSEIQGNHD LLMSYELGPV EGGFSGSRRV
KEKISSFLPH IIGEFHLDAT KEASSLRALI EKPPIHKEIS NLTSSSMQGF KLSAGPVDER
YRHLFERRKE EPNLAYSEKL NLIRVRQQYD AYGFDDDETE KGFPKKHKKK KKDKKRKKEK
EELGDAEKRK RAADEPMEF
