ID   MED19_CANGA             Reviewed;         201 AA.
AC   Q6FJ36;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=ROX3; Synonyms=MED19; OrderedLocusNames=CAGL0M09515g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380959; CAG62736.1; -; Genomic_DNA.
DR   RefSeq; XP_449758.1; XM_449758.1.
DR   AlphaFoldDB; Q6FJ36; -.
DR   STRING; 5478.XP_449758.1; -.
DR   EnsemblFungi; CAG62736; CAG62736; CAGL0M09515g.
DR   GeneID; 2891322; -.
DR   KEGG; cgr:CAGL0M09515g; -.
DR   CGD; CAL0136373; CAGL0M09515g.
DR   VEuPathDB; FungiDB:CAGL0M09515g; -.
DR   eggNOG; ENOG502QXG3; Eukaryota.
DR   HOGENOM; CLU_117719_0_0_1; -.
DR   InParanoid; Q6FJ36; -.
DR   OMA; AYYYYVD; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0001113; P:transcription open complex formation at RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR013942; Mediator_Med19_fun.
DR   PANTHER; PTHR28270; PTHR28270; 1.
DR   Pfam; PF08633; Rox3; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..201
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304776"
FT   REGION          166..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  23358 MW;  55C70B7CD62EF5BC CRC64;
     MEMEEFAPSY YYYVEPEMGY QPQQPNPMED LITVYHLDDI SRQVARTNED GTKAVKLRKS
     YKNQITDLSG KFSSIPNREN RKGGEIAHIL FQNNPDMMNQ VHRSPDMTDE QWREALMNVD
     ASLFQAPNMD WEVCQSVLSQ FDRSYPTEFQ NDPNFHVDDL AFDLDGTGKS NAKKRKNRSN
     GSSMATPNSE MQDDVKRRRL E