ID   MED19_CHAGB             Reviewed;         326 AA.
AC   Q2GW22;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 3.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=ROX3; Synonyms=MED19; ORFNames=CHGG_07832;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; CH408033; EAQ86579.1; -; Genomic_DNA.
DR   RefSeq; XP_001225488.1; XM_001225487.1.
DR   AlphaFoldDB; Q2GW22; -.
DR   STRING; 38033.XP_001225488.1; -.
DR   EnsemblFungi; EAQ86579; EAQ86579; CHGG_07832.
DR   GeneID; 4393188; -.
DR   eggNOG; ENOG502QXG3; Eukaryota.
DR   HOGENOM; CLU_037869_0_0_1; -.
DR   InParanoid; Q2GW22; -.
DR   OMA; AMQMEPG; -.
DR   OrthoDB; 1199699at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013942; Mediator_Med19_fun.
DR   Pfam; PF08633; Rox3; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..326
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304777"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  36016 MW;  03801CC39AC21F6B CRC64;
     MSCHPQTPQS PSQFSPNTSD LMMSMTGSVT STTTTLPTPA HSVNGSSIPS ELTQDTAMGD
     DSPHKRKRDG DDMGSRAQKK VHVEDRKLGI DDLHMDVGEK YLLCRTPHPR PRPHVSEDLF
     EMYGLTGLAI EVARVRPNGE KNALRKTYKG HIKRLGVQGH FDEDKQDPNR EYSLSHLMKL
     PQDVWDLQHV RGQDIRDGFT NEVQQKLSRA MTMGRGVVPR DQWDSSVLGE MGPGKGERQA
     LSARPTAPNT PLPSAGPQGL PRPKTGTPLM QDASRSMRTI KKRSYGDSSF EGYGESYDDG
     ADTGYSTGEG DMSSGQKRRK KVLIND