ID   MED19_DICDI             Reviewed;         299 AA.
AC   Q55BA4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Putative mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Putative mediator complex subunit 19;
GN   Name=med19; ORFNames=DDB_G0271246;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=18515835; DOI=10.1093/nar/gkn349;
RA   Bourbon H.-M.;
RT   "Comparative genomics supports a deep evolutionary origin for the large,
RT   four-module transcriptional mediator complex.";
RL   Nucleic Acids Res. 36:3993-4008(2008).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71753.1; -; Genomic_DNA.
DR   RefSeq; XP_645708.1; XM_640616.1.
DR   AlphaFoldDB; Q55BA4; -.
DR   PaxDb; Q55BA4; -.
DR   EnsemblProtists; EAL71753; EAL71753; DDB_G0271246.
DR   GeneID; 8617901; -.
DR   KEGG; ddi:DDB_G0271246; -.
DR   dictyBase; DDB_G0271246; med19.
DR   eggNOG; ENOG502RHEN; Eukaryota.
DR   HOGENOM; CLU_931990_0_0_1; -.
DR   InParanoid; Q55BA4; -.
DR   OMA; MNHNNNM; -.
DR   PRO; PR:Q55BA4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:dictyBase.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..299
FT                   /note="Putative mediator of RNA polymerase II transcription
FT                   subunit 19"
FT                   /id="PRO_0000388657"
FT   REGION          60..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          260..291
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        68..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  33974 MW;  BE5296A6847FCF1F CRC64;
     MSSSLYLINP IEKSSENITG ETNLLEHFNL YKTLNEFNSK HLSSTYKSYV KNLPGDNYIK
     REKSKHSSSS SSNNNNNSNN NNNSNNTNAS GQQDVNMGVP PQQQQQQQQQ QQQQQPQQPQ
     QPEPPKPPGG LTRLVEGNFF DENQQELILL SLDDSQLRSA FTLLDGGYQR PDKDKKRDKK
     HRDKKKRKHR DGSSSSSTSG EKKKSKKDRP DGSHHHSNSN NNNSGNSMNS NNMNNNNLNH
     NNNNNMNHNN MNHNNNMNHN NNMNNNMNNN NNNNNNNNNN NNNNNMNNNN NGGNITVEH