ID   MED19_PICST             Reviewed;         173 AA.
AC   A3LV29;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=ROX3; Synonyms=MED19; ORFNames=PICST_67785;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000499; ABN66701.2; -; Genomic_DNA.
DR   RefSeq; XP_001384730.2; XM_001384693.1.
DR   AlphaFoldDB; A3LV29; -.
DR   STRING; 4924.XP_001384730.2; -.
DR   EnsemblFungi; ABN66701; ABN66701; PICST_67785.
DR   GeneID; 4839637; -.
DR   KEGG; pic:PICST_67785; -.
DR   eggNOG; ENOG502QXG3; Eukaryota.
DR   HOGENOM; CLU_121530_0_0_1; -.
DR   InParanoid; A3LV29; -.
DR   OMA; QDLPGKH; -.
DR   OrthoDB; 1570473at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013942; Mediator_Med19_fun.
DR   PANTHER; PTHR28270; PTHR28270; 1.
DR   Pfam; PF08633; Rox3; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..173
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304780"
FT   REGION          139..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..156
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   173 AA;  19165 MW;  945B9F551886A2F2 CRC64;
     MVNDNYNTAE GIDSYYLVNS KHKYSITSPS PLDNLLVLYG LEPIAKSLAR TNADGSKGVK
     LRKSYKNHIQ DLPGKHQIVG GQKPIPAGLL DPMVAQAPDI IKELDPELLS RGLRFEKTPI
     NGIPGFNTAD LAINDQHTLM RGDDMSENDE FGARRSKRKK KAQNGTDSKR QHI