ID   MED19_XENLA             Reviewed;         240 AA.
AC   Q5EAY2; Q8AVJ5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=med19;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg, and Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; BC042241; AAH42241.1; -; mRNA.
DR   EMBL; BC090202; AAH90202.1; -; mRNA.
DR   RefSeq; NP_001167490.1; NM_001174019.1.
DR   AlphaFoldDB; Q5EAY2; -.
DR   SMR; Q5EAY2; -.
DR   MaxQB; Q5EAY2; -.
DR   DNASU; 100381081; -.
DR   GeneID; 100381081; -.
DR   KEGG; xla:100381081; -.
DR   CTD; 100381081; -.
DR   Xenbase; XB-GENE-6256048; med19.L.
DR   OrthoDB; 1484317at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 100381081; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019403; Mediator_Med19_met.
DR   PANTHER; PTHR22536; PTHR22536; 1.
DR   Pfam; PF10278; Med19; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304770"
FT   REGION          32..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        204..205
FT                   /note="QR -> KK (in Ref. 1; AAH42241)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  26264 MW;  EDCEC5C69CD855F9 CRC64;
     MDGFSALFVP SEPSVPGSQS VVPTCTGAFV SGKTQAQTPI PGPPPTLPSS SSVEDNSRRP
     AAGPFYLLRE LPGLSDLTAS INLILHYNLE HSFSKFCGKK VKEKLSNFLP DLPGMIDTPG
     TPDNSSLRSL IEKPPICGNA FTPLTGALLT GFRLHTGPLP EQCRLMHIQP PKKKNKKHKQ
     SRTQEPAPPE TPSDSDHRKK KKKQREDDPE RRKKKKDKKK KKSRHSPEHP GAGSSQSGLR