ID   MED19_XENTR             Reviewed;         249 AA.
AC   Q07FY3; Q5I0A6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19;
DE   AltName: Full=Mediator complex subunit 19;
GN   Name=med19; ORFNames=TEgg003p13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-249.
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; CR942536; CAL49313.1; -; mRNA.
DR   EMBL; BC088543; AAH88543.1; -; mRNA.
DR   RefSeq; NP_001095276.1; NM_001101806.1.
DR   AlphaFoldDB; Q07FY3; -.
DR   SMR; Q07FY3; -.
DR   Ensembl; ENSXETT00000066323; ENSXETP00000058902; ENSXETG00000032150.
DR   GeneID; 100124299; -.
DR   KEGG; xtr:100124299; -.
DR   CTD; 219541; -.
DR   Xenbase; XB-GENE-940493; med19.
DR   InParanoid; Q07FY3; -.
DR   OrthoDB; 1484317at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000032150; Expressed in gastrula and 12 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019403; Mediator_Med19_met.
DR   PANTHER; PTHR22536; PTHR22536; 1.
DR   Pfam; PF10278; Med19; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..249
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19"
FT                   /id="PRO_0000304771"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..222
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   249 AA;  27008 MW;  DAE4A1D06F952F72 CRC64;
     MEGFSGLFAA SEPSSIPSAP GPPSVVPTCT GAFVSGKTQT STPTVPGPPL PIPPPLSSSS
     SGEDSSRRPA AGPFYILREL PGLSDLTGSV NLILHYNLEH SFSKFCGKKM KEKLSNFLPD
     LPGMIDTPGA QDNSSLRSLI EKPPICGNSF TPLTGALLTG FRLHTGPLPE QCRLMHIQPP
     KKKNKKHKQS RTQEPAPPET PSDSDHRKKK KKQREDDPER RRKKKDKKKK KSRHSPEHPG
     AGSSQSGLR