ID   MED1L_CAEBR             Reviewed;         523 AA.
AC   Q614K9; A8XNE3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1.2;
DE   AltName: Full=Mediator complex subunit 1.2;
GN   Name=mdt-1.2; ORFNames=CBG15955;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600995; CAP34374.1; -; Genomic_DNA.
DR   RefSeq; XP_002643356.1; XM_002643310.1.
DR   AlphaFoldDB; Q614K9; -.
DR   SMR; Q614K9; -.
DR   STRING; 6238.CBG15955; -.
DR   EnsemblMetazoa; CBG15955.1; CBG15955.1; WBGene00036052.
DR   GeneID; 8585350; -.
DR   KEGG; cbr:CBG_15955; -.
DR   CTD; 8585350; -.
DR   WormBase; CBG15955; CBP10211; WBGene00036052; Cbr-mdt-1.2.
DR   eggNOG; ENOG502TFH1; Eukaryota.
DR   HOGENOM; CLU_521997_0_0_1; -.
DR   InParanoid; Q614K9; -.
DR   OMA; EMRMEQV; -.
DR   OrthoDB; 656853at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..523
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1.2"
FT                   /id="PRO_0000302026"
SQ   SEQUENCE   523 AA;  60356 MW;  C088CE6A2A3A151C CRC64;
     MPRDIPATKG VYLLERVTNK EINLENIDEE MRMEQVRQAG AKLDWASFGQ AVRRNLQEKR
     NTIDADGRID VLKSLAFMKT KLPIEADAPM EEKIRILAES LGCTHVRTTR GWTITKPEEL
     NVDLTIKNGE VDTVVLSFWE EAAFYSGEAT KMLHKGEWSE LRDRLASMLA VYNKDLDRND
     RKTCKAAMDV LGSMLKTMNA DEMYTSIQNN NYGYYLHRSD LRQGRLYYNV EPLYRRVRSK
     HHTYSLQKED WDILPFFEFS FVPSDSVHAF PEHNPYGEWK ETGSAKAAVC LKLSKGVLVS
     EPTRRKLHEI SARSTTIQCY TNCYRYLTGS VLIKDNLKMI TQFPGECTQH HYTIDRSSFT
     SEGDSVITEI YLKRLQDFHK VIEILRKEAM HISIWESVLA DCYELQGLEE RVVPAINMFV
     NLSRDMITVR FMTKYAPIRV CIRDGVWIEA KVEVVNDQTG AKVADRVDEL LTRKLNETWS
     IPIMLTFAVS GEDCALEQMK VPLREENPET KLPTPTKIIV HKN