ID   MED1L_CAEEL             Reviewed;         522 AA.
AC   O02042;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1.2;
DE   AltName: Full=Mediator complex subunit 1.2;
GN   Name=mdt-1.2; ORFNames=T23C6.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; FO080162; CCD61703.1; -; Genomic_DNA.
DR   PIR; T15119; T15119.
DR   RefSeq; NP_510778.1; NM_078377.4.
DR   AlphaFoldDB; O02042; -.
DR   SMR; O02042; -.
DR   BioGRID; 46632; 8.
DR   IntAct; O02042; 9.
DR   STRING; 6239.T23C6.1; -.
DR   EPD; O02042; -.
DR   PaxDb; O02042; -.
DR   PeptideAtlas; O02042; -.
DR   EnsemblMetazoa; T23C6.1.1; T23C6.1.1; WBGene00007011.
DR   GeneID; 181755; -.
DR   KEGG; cel:CELE_T23C6.1; -.
DR   UCSC; T23C6.1; c. elegans.
DR   CTD; 181755; -.
DR   WormBase; T23C6.1; CE07526; WBGene00007011; mdt-1.2.
DR   eggNOG; ENOG502TFH1; Eukaryota.
DR   GeneTree; ENSGT00970000196378; -.
DR   HOGENOM; CLU_521997_0_0_1; -.
DR   InParanoid; O02042; -.
DR   OMA; EMRMEQV; -.
DR   OrthoDB; 656853at2759; -.
DR   SignaLink; O02042; -.
DR   PRO; PR:O02042; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00007011; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..522
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1.2"
FT                   /id="PRO_0000302027"
FT   COILED          13..40
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   522 AA;  60120 MW;  77506BC11C098F53 CRC64;
     MVSTPSPKTK VYLLEQRKNQ ELNIEHIDEE MRLEQVRQAA SKMEWTSFGQ AVRRNLLEKR
     NTIDADGRID VLNGIAYMKT KMPIEENNLM EEKIRVMAES LGCLHKQTSR GWSINRQEDL
     IMDFTVNDGE VTTVVLSFWE EPSFYSPEAT RMLQLGMWTE LRNRISDMLL TYDKLLSRDD
     RRNCMGAMRM LEMLFGHFSQ DPSYTSIHRS NYGFYLPRND LRAGRVYYLA EPHFRNIRSK
     DHIFQLQKDD HEVLPYFEFS FAKHDSPCTL PEFDTKGWAE SIEANAVICM KLSRGFNLTE
     TTRKKLGAIS AKTPSVKHFT NSYRYVTGAV KIENNLQMIT QFGDGQTQHF YNVDVNQLRN
     DGDSVITEIY LKHLQDFHEI IAILRNEAMH ISLWESMISA CYEKQGMKKH TVAAIKMDVF
     LTREQIVITF DTKFAPVKVV IQDSGVCEAK VNVVHAQTGL QIAEKIDETL SRKLNETWSI
     PNMLTYAVSG SDCNLAKIKV PLRSENPETV GPIPTYAAGR SF