ID   MED1_AEDAE              Reviewed;        1760 AA.
AC   Q172G3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1;
DE   AltName: Full=Mediator complex subunit 1;
GN   ORFNames=AAEL007402;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477438; EAT40905.1; -; Genomic_DNA.
DR   RefSeq; XP_001652740.1; XM_001652690.1.
DR   AlphaFoldDB; Q172G3; -.
DR   STRING; 7159.AAEL007402-PA; -.
DR   PRIDE; Q172G3; -.
DR   VEuPathDB; VectorBase:AAEL028220; -.
DR   eggNOG; ENOG502QPZ7; Eukaryota.
DR   HOGENOM; CLU_004475_0_0_1; -.
DR   InParanoid; Q172G3; -.
DR   OMA; HAMKLTY; -.
DR   PhylomeDB; Q172G3; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   InterPro; IPR019680; Mediator_Med1.
DR   Pfam; PF10744; Med1; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1760
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1"
FT                   /id="PRO_0000302022"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          827..1078
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1188..1218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1269..1401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1455..1510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1540..1640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1701..1760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..660
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..685
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..715
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        722..765
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..879
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        880..897
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        914..1040
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1041..1058
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1059..1073
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1480..1508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1540..1573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1589..1640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1701..1723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1760 AA;  181862 MW;  EDA31A08993BACC9 CRC64;
     MSSIHSKVVI GEKRREMSST AAGGSLPASI MANGSGKPIK MEMKPIVGTT AAGKGHGGLL
     PGSGDKHESW QMELLMERLR NKAKSSQYKS FQEMSKAVRM SLLEKRYALD AVEKSNLQKT
     LDSMQYCIKV TSRQGLVERL DCLTRQLGLK LSEDTSGLFI SSDMFYLEII LDPNGTVQDV
     KVHHECKMKQ QSCSELVSCL QRGDFVDFTT QLEGLASIYQ LNAEKKIKVN AFVALQALET
     DLYNLYTLST QHYNDIHSLL LKSPLGVVQK RRGGHAMKLT YYIAPYDLLD LEARKMKPLN
     TELISAEKIG YSVAVNLEAS TANKLQIQPL LVQQGNSPVY SPIEKHNSTS LPATFVLRLN
     KPMALNVAML KQIKHITGDS SAVTIDPATS NTCLMSLIVQ HASNGTVNNI AKGLFVTLPD
     QYHCYYMTEN KNLQGTIISS IPFTEPQHVS KILVFLRQQA LFNQLLTSCI RNNGSSSTRM
     SDYEHLVVFE VAALSCQYIT VSLEHPFEES IAMVEFDLRN ILAIQVRVFC NGYESDERIS
     KQVSLIVQRT MSIPVTLRGL MKIWQEDYEV KFKGQGNGGG NGTVDEGNFS LSMGPDEGGG
     NGPAGPGGGG GGGSAMNGQH NGSLNGSGME FCDVKKVKLE PMDQSKKRRG VEDFCRSPKS
     SKVESEGGNE AMDEEDDDDE YDESTNLSSG DSNSLGENQQ TNAGQSSSST AAMGAPAPVS
     TVGPRNSVSG NASESSGNSS ILGSLDFSSL DPDLMRSSNS SDLDDTTEVS EPEVKVKSEE
     PSYATSVSIT PIGVGKSTSS LTNSVLNNIG LDKRPGIEII PLANAGTNVP SSITITPIPM
     GSSGGSLKSS SDNSGDKKLS SSSSGSIHRK SGSSSSSSES DRAKLEKKKK RRHEEQLAQL
     QQMGPPHKIL SKSTDGPASP SGSSRKFSVS PVPLKSGSGS SSSQIFLSSG SPGSGSKSSP
     KHSPVHHSSP KHQGSYGTSS PKHISGGSSG GGKPSMSALK SATSSGSPSS KNGSSGIGGS
     GKEEGSSGSG SKSSGSGGSS SSRDRDRDRD RDRGEKRSGY SSSSSSSSPK LKTPAVKLKQ
     LDLTNCGSTV SAGVQLELMN SNSSGGSSSG SGSIDLTDSA LFGIGATDLS KNASAAAASA
     AGMLLLQQAM KRKGSLSAVI DKLKSAQGGD ESSLMLLPEL AQQAGFSLKD ASTPGKTASS
     SLPVASSSSA SSSTSSTSVS NLTGASLGSA SAAAAAALAA HFSSAAAAMQ GKTSEYMVKP
     SSDGIKLTIQ NKKGSKSGSS SSSTSSSSSK SSSSKSGTKP SISSGSLPPK KLPSSQSFSG
     AYPPTSGSSS SSSGKSFSSG SSSSSSSKAP FQKSSSSGSL SSSGSSMRPS SKSSTSSSGS
     SKDKSRSSSK SSSSSSAAAA AASSLMATNA AMAAAAQAAV NANALNVMKM LGLTSSIQNM
     EGFVKTLDTK FQIPKLSARS GGSSGSGPGG SDIEKLKQES RPLSSSSAPT TPLSNVGQSP
     TGSNDFSLPF NKLPGDVSPL HSTLLPNVMQ KMFSGHDTSM LMRRSPNLDH QSSSNSRDGF
     SSIYGKGSTT PTTPTGSVPP PFPSPGNVQS HAMDFSNSSD SADASLMRPP SRPSSTMSNH
     SSSDKLIDAT TNSNSMDGLR STSPAQALAA AAVAAQLMNK LDNTQQFVAA LKNHHHHLSA
     LSLSNAAAVA ASQLAAAAAS ASSGGSAGPG PVTSPTSVSV HIMKSPVPSP LPLHGGGGAA
     SSSSVGGPDE DETLVGVSGK