ID   MED1_ASHGO              Reviewed;         426 AA.
AC   Q75BA8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1;
DE   AltName: Full=Mediator complex subunit 1;
GN   Name=MED1; OrderedLocusNames=ADL341C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016817; AAS51578.1; -; Genomic_DNA.
DR   RefSeq; NP_983754.1; NM_209107.1.
DR   AlphaFoldDB; Q75BA8; -.
DR   STRING; 33169.AAS51578; -.
DR   EnsemblFungi; AAS51578; AAS51578; AGOS_ADL341C.
DR   GeneID; 4620010; -.
DR   KEGG; ago:AGOS_ADL341C; -.
DR   eggNOG; ENOG502QW0Y; Eukaryota.
DR   HOGENOM; CLU_021764_0_0_1; -.
DR   InParanoid; Q75BA8; -.
DR   OMA; NDKFGIY; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR019680; Mediator_Med1.
DR   Pfam; PF10744; Med1; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..426
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1"
FT                   /id="PRO_0000302028"
FT   REGION          324..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  48584 MW;  894F292D2A125921 CRC64;
     MPDAYVESLG KMIAILVNYK PGSITLENIT RLCQTMGLES FVDQVSANIS RLSIASKIIV
     IDIDYEVTDG KVIDVKLVLA SNFDKFDYFN GEANILHRSL TTYSDLHEFH HNLKFLTLLD
     ACSSIDIESN VSQFDLFEYY SMLPQYMQSY LDDNGAQLTV QTNLNDRFGI YLLDHSEKKV
     AKLTFAATQD PNQRYYEYKY SSETKEWINQ SAESYTTGIT LVFELLGDPP TYLPKDSLPP
     EHPDEGFTSA SASELQRRFA FKCQNPRVTL VNDFTVDVYP ASTFQLLNDN ICLCFDILRR
     QKWWHTVLYP ISQLLLHQGQ DSAVGDAPAP AAQPPLHRRR SSNKGCRRAS AAESATLGDE
     NMHQLTLTEI MNKSVIPEDD AMMDDRIELY VNENYVYLGT QEGCSFYNDP IERWEAFVES
     LRQMLT