ID   MED1_CAEBR              Reviewed;        1529 AA.
AC   Q61X54; A8WW94;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1.1;
DE   AltName: Full=Mediator complex subunit 1.1;
GN   Name=sop-3; Synonyms=mdt-1.1; ORFNames=CBG04122;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600956; CAP24903.3; -; Genomic_DNA.
DR   RefSeq; XP_002639516.1; XM_002639470.1.
DR   AlphaFoldDB; Q61X54; -.
DR   STRING; 6238.CBG04122; -.
DR   PRIDE; Q61X54; -.
DR   EnsemblMetazoa; CBG04122a.1; CBG04122a.1; WBGene00026857.
DR   GeneID; 8581509; -.
DR   KEGG; cbr:CBG_04122; -.
DR   CTD; 8581509; -.
DR   WormBase; CBG04122a; CBP14985; WBGene00026857; Cbr-sop-3.
DR   eggNOG; ENOG502QPZ7; Eukaryota.
DR   HOGENOM; CLU_255799_0_0_1; -.
DR   InParanoid; Q61X54; -.
DR   OMA; SHSYHGM; -.
DR   OrthoDB; 656853at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032587; C:ruffle membrane; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1529
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1.1"
FT                   /id="PRO_0000302024"
FT   REGION          685..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          807..919
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..1529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1008..1032
FT                   /evidence="ECO:0000255"
FT   COILED          1169..1202
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        807..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..904
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        940..985
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1006..1038
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1046..1108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1116..1241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1258..1278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1279..1293
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1300..1326
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1346..1369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1472..1501
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1529 AA;  170840 MW;  AAC9548B9241801A CRC64;
     MIIEERKSHE LNLESIDNDL RLESVRQNAE KLGWDHFARS VRRNLQEKHH TLEASIRLDV
     LGSLAFMKAH LPIDKDESLN RKIQSLADGL GENCVVAAHI GGISIKSHDV SVDIGIAEEA
     IVSCKIGYFG QPLFDAPEAL ALLKSDEFSK LRDSIAEVLS LIPKEISLSD KNACKDALRA
     LEHVLIRDAA DSSFSAINNN KYGFYSPRNE LRPGRLYYIA EPMLIRVAEK EGKMHADNSH
     LDSLPYIEIF FVKSNKKSKL PVFNQSGEWT TFNDAKVCIC IRFKHAFLFS QHTIRKLAKT
     VPKSPVVRSY VNFYRYATGR PTVKKNLELL TQFPNETDIQ QHYNVDSSKL ASDSDSLVVE
     MFLGDLRELP KLIETLRSEW MHASLWESIV AMCEPNQDAV KKEVRAANLE LLLRRNEFNL
     KFDTEFGNMS MQISEKEPRR YFIRTVSQLT GDTPSSDLDN LLTEKLNSTW SIPISLTFAL
     STLNCRLNSL LSPLNYVKPS NPFDSDKRQQ WWLGANKTHT NITVEKVKKR IVLEIGPVIE
     PKELVYTRQE DEELCGSLLS SFGEVDQYYV QTSTIGKTGP QPRPKREPSQ LASMGMMSAE
     LDMARNRQSM EHAMHPRPQD LRELSNLESA RIQMRQSIGA AHAVGLASHQ SFTSPGPMRH
     HPYMGGSYDS PGFYGPNIPA SVPFPDAAAF GKGKQRKPRA KKQPGEEVAA PSGRGKGRKG
     RGAAAVGAGS GRKSSGVVGE NQYGMDQMRP QLQRSYSDFQ NPMNPQHMPQ YAQHMQHMQQ
     MHQMQNMQQY QQMQQYQQNQ QYQQNQQYRM HMQQQQLQQQ QMQSPQQQSG MNTPKSQRLT
     DEDSDEDVDP PRLPKPQVSA AVSRPSLPPP HQLGNPMVGY PGMPLQSPNH LPLTPSPLSA
     PPKPFSPEQH HFGTKMRDNA YWKEAERNID VKPDIEKLKQ QMAASSSCGP VLGTAATSSS
     SDPSTSGESS NATESASSAP LMKPPTTAQT PKKKLGLEAT LSKLRGVQEQ ALQKQEQQRI
     QQQDSVDSTN SEQPTPQPQF SQQPGPPLAP NQVNRVMNMS NAFDDEAGSS TNTSDIKPSL
     ASLQKSTGSI VVDPTTPGTS SNIAQPSGVM PSLKKEVEEQ PPEREKEKLI VKIPKILKVD
     DRRDERREKE RDRDRDRDRD GDRERDRYEK EDKSQREKDK KERDKERKRR DRDRTEAKKE
     KDSSGTREKE SKKRKREKSE EKDKREPDRK KEKKEGKELS KTTTKSVLPM IPTRTLKNFR
     IPKKDTVDED KKEPKDESIP GPSTSSESST RKEVAPAPIS RKESTTSSVA PLQRKESFTS
     QSGAFPPSEY HREPPKKKPP PISGPAQGSY SGSSNAGPIS SSSRGSGNGG SRKPPVLPPP
     ALPMRGPPSD QMYRERTGSM RGFPPSSHYH GSGGSGGSKQ VASYAQGLPP GMGPPAAKPH
     GNSYQASQWV RPPTHRDSHS YHGMPTLGPP QISQREQPPP PPQMIPLPKE NPPPPLAPPS
     RPHRDSRARG GGDNGPDSPE EGTLRIDDE