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MED1_CAEEL
ID   MED1_CAEEL              Reviewed;        1475 AA.
AC   Q9N4G4; Q95Y43; Q9GPV1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1.1;
DE   AltName: Full=Mediator complex subunit 1.1;
DE   AltName: Full=Suppressor of pal-1 protein 3;
GN   Name=sop-3; Synonyms=mdt-1.1; ORFNames=Y71F9B.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX   PubMed=11171401; DOI=10.1242/dev.128.5.767;
RA   Zhang H., Emmons S.W.;
RT   "The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox
RT   gene expression.";
RL   Development 128:767-777(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9N4G4; Q8MPT2: T04C9.1; NbExp=6; IntAct=EBI-2315681, EBI-2315635;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q9N4G4-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q9N4G4-2; Sequence=VSP_027908, VSP_027909;
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF308860; AAG45416.1; -; mRNA.
DR   EMBL; FO081276; CCD70417.1; -; Genomic_DNA.
DR   EMBL; FO081276; CCD70418.1; -; Genomic_DNA.
DR   RefSeq; NP_001021811.1; NM_001026640.3.
DR   RefSeq; NP_740821.1; NM_170837.3. [Q9N4G4-1]
DR   AlphaFoldDB; Q9N4G4; -.
DR   BioGRID; 37321; 3.
DR   IntAct; Q9N4G4; 2.
DR   STRING; 6239.Y71F9B.10a; -.
DR   iPTMnet; Q9N4G4; -.
DR   EPD; Q9N4G4; -.
DR   PaxDb; Q9N4G4; -.
DR   PeptideAtlas; Q9N4G4; -.
DR   PRIDE; Q9N4G4; -.
DR   EnsemblMetazoa; Y71F9B.10a.1; Y71F9B.10a.1; WBGene00004946. [Q9N4G4-1]
DR   EnsemblMetazoa; Y71F9B.10b.1; Y71F9B.10b.1; WBGene00004946.
DR   GeneID; 171840; -.
DR   UCSC; Y71F9B.10a.1; c. elegans. [Q9N4G4-1]
DR   CTD; 171840; -.
DR   WormBase; Y71F9B.10a; CE28808; WBGene00004946; sop-3. [Q9N4G4-1]
DR   WormBase; Y71F9B.10b; CE29912; WBGene00004946; sop-3. [Q9N4G4-2]
DR   eggNOG; ENOG502QPZ7; Eukaryota.
DR   GeneTree; ENSGT00970000196378; -.
DR   InParanoid; Q9N4G4; -.
DR   SignaLink; Q9N4G4; -.
DR   PRO; PR:Q9N4G4; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004946; Expressed in embryo and 4 other tissues.
DR   ExpressionAtlas; Q9N4G4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1475
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1.1"
FT                   /id="PRO_0000302025"
FT   REGION          579..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..1475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1098..1135
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        580..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        754..804
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..879
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        913..943
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..990
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1027..1052
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1053..1178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1198..1220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1221..1266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1279..1308
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1317..1332
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1389..1403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1419..1440
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1441..1475
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         536..544
FT                   /note="VTVLEVGPA -> ELYALTTSK (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_027908"
FT   VAR_SEQ         545..1475
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_027909"
SQ   SEQUENCE   1475 AA;  164547 MW;  C0A80E70DE9CC98B CRC64;
     MIIEERKNHE LNLESIDRDL RMENVRQSAE KLGWEHFARS VRRNLLEKRQ TLDARTRLDV
     LGSLVFMKEH LPIDNDATIA RKVQQLSEGL GEHCVFSTQN SGFSIRNPDV TIDIGVAEDQ
     ISTCKIGYFG QPLTDAPGAL ALMKNGEFSK LRDSITAILS SLPKEITLSE KNACKEAFRA
     LDQLLIRDAA DSSFTAINTG KYGFYAPRNE LRSGRIYYVA EPVLIRLAEK EGKTKADASY
     LDLLPYIEIS FFKHDKPSKL PVFTQTGEWS TFNDANVCIC VRFNQGFLLS QQTIRKLSHI
     VPKSPLVRNY VNFYRYMTGR VGVKSNLKLL TQFPDEGDIQ QQYQVDSKML TKEDDVVAME
     MYLSDFRDLS KLIETLRSEW KHASLWESIL AICESSKGEQ KEVNAVDMQL VLRRTEFFLQ
     FDTDYGSMTM QIFEKSPSNY VVKTTSQITG ESPSLDFDKM LTEKLNSTWS IPATLTFAIT
     DLKCRINSVL NCVISFDSSS SSDKQHQNYW SISNNNTQLM QSAAQKSAAK CTKKKVTVLE
     VGPAIEPTQL VYTRENDEEF QGSLLSSFGE VDDYYVKTST IGRTRPQPRP KREPNQLTSM
     DMMSAELDKS RHTMEGSMRD AQTSSFLDAA RVRMKQSIGA AHAVGLASHQ PPASPVAAAA
     AAPGGPMRHN SYPSGFEPPP SVAPYDFPAD PSKKQRKQRA KKQPGEEPPA GRGKGGKKGR
     GAGAVGAAAA GGRKSAGGAG ENPFGMDPMR PPMLQRSSSE QHNPNPHQMS QYQMQQYQQN
     QQFRMHQMQQ QQQQQFQMQS PKNPLVPAYT DEDSDEECDP PPPPKPQVST SSRMSSVPSH
     PPPPPQQLGN PMVGYPGMPL QSPNHLPLTP SPLSAPPKPF SPEQQHHFGM KMRETSYWKE
     LERLETKPDV EKLKQQLSSS SSSSQAEASD PPSTSTEAQD PPKPSSSSAP PPPKKKLGLE
     AAISKIRGQQ EQALQKQLQQ QESVESELAT PHPGSSGAPP LAPHQVNRAR NLNDIFDDEA
     DDSSPTADIK PSLQALQKPT DTSSQSTSSE PPPKKEPADE QPEREKEKLI LKIPKMLKPV
     VDDRREDRKE RDRDRDRDRD RDEDREKVRD KEDKAQREKD KKEKERERRR QRDRDRTEQK
     KSDREKEPSK KRKLEKKDEK EKDRREPERK KGKSDGKEYS KASTTSLIPT LSLKNFRIPK
     KDTVEEEKKD VKEEAPGPSS STESKKEPPS AAPITRKEST TAPVAPAVQQ QQQRKESFTA
     LPSLPEQQQH HREPLLKKKP PLQPPPPPQM TGPPIGIYPG PPAPGNLPGS SRPSGNRKQP
     LPPPPPMIRG PPPDQMYRDR SGGGGGSMRG GFPPASHYHG GTSGVNKQVA SYAQGLPPGM
     GPPVVKPHGN NYQASQWVRP PTHRDSSHSY HGMPSLGPPQ LQREPPAPPP PQMIPLPKDP
     PVLREHPREH RAHRGGADDD GPDSPEEGTL RIDDE
 
 
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