ID   MED1_CANGA              Reviewed;         565 AA.
AC   Q6FWB9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1;
DE   AltName: Full=Mediator complex subunit 1;
GN   Name=MED1; OrderedLocusNames=CAGL0D01386g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380950; CAG58386.1; -; Genomic_DNA.
DR   RefSeq; XP_445475.1; XM_445475.1.
DR   AlphaFoldDB; Q6FWB9; -.
DR   STRING; 5478.XP_445475.1; -.
DR   EnsemblFungi; CAG58386; CAG58386; CAGL0D01386g.
DR   GeneID; 2887120; -.
DR   KEGG; cgr:CAGL0D01386g; -.
DR   CGD; CAL0128307; MED1.
DR   VEuPathDB; FungiDB:CAGL0D01386g; -.
DR   eggNOG; ENOG502QW0Y; Eukaryota.
DR   HOGENOM; CLU_021764_0_0_1; -.
DR   InParanoid; Q6FWB9; -.
DR   OMA; NDKFGIY; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR019680; Mediator_Med1.
DR   Pfam; PF10744; Med1; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..565
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1"
FT                   /id="PRO_0000302029"
FT   REGION          141..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   565 AA;  64679 MW;  D4F577F0ADB0FE8C CRC64;
     MADQYVEVLG DLIGLLKDYK PGTITIENIT KLCQSMGLES FIDELDNDIS RLSTASKIIV
     IDIDYNKTQS TVQDVKLVLA SNFDNFDYSN EQLEEAGDKQ SNILLNSLTN YDSLKQFHHN
     LEFLYLLDTY SSVESDNQIS SGNNLGSGNG TNGSSLTNKT DKKSVSSGNG LDSKLNEGKL
     NLFKYFRELK KYINTFFKES CDNRFKVVAN VDNRFGLYIY ETHGYSMRSR PLAKVYFERA
     KVPQQRFYEY IYSSETGSWI NENSENYSVG VNLILEVNFD DTDEDVFWFP KEFVPTDLFI
     DEKDQLTSRK VSDVLCHAFY ELGSSKKQTI ELMNDFTTDL IQIRRFNINN DNLDLIADIL
     NWTIWYRTVL RPIYLKLVSS ISDDDDQHIR ADIANTKDEF TVENTNPEIM KGPTNKNASF
     MQRNSMSLQR RRRSSNKAKR PSMSEAVVFK DEGLQQFSLH EIMADTTTEP DQKPDNLNIS
     NNSESFIGQQ ELMEGSNIIN DDKMDIDEEA INDDDSDSQS GEEGNIPVLL VNEDHVSFKG
     LGSCSFYDDK DKWAKFVEDL FNVFS