ID   MED1_XENLA              Reviewed;        1570 AA.
AC   Q6INP8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 1;
DE   AltName: Full=Mediator complex subunit 1;
GN   Name=med1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity).
CC       {ECO:0000250|UniProtKB:Q15648}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000250|UniProtKB:Q15648}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15648}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 1 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072226; AAH72226.1; -; mRNA.
DR   RefSeq; NP_001085198.1; NM_001091729.1.
DR   AlphaFoldDB; Q6INP8; -.
DR   SMR; Q6INP8; -.
DR   MaxQB; Q6INP8; -.
DR   PRIDE; Q6INP8; -.
DR   DNASU; 432291; -.
DR   GeneID; 432291; -.
DR   KEGG; xla:432291; -.
DR   CTD; 5469; -.
DR   OMA; HAMKLTY; -.
DR   OrthoDB; 57581at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 432291; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   InterPro; IPR019680; Mediator_Med1.
DR   Pfam; PF10744; Med1; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1570
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   1"
FT                   /id="PRO_0000302020"
FT   REGION          592..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          771..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..1561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           585..589
FT                   /note="LXXLL motif 1"
FT   MOTIF           626..630
FT                   /note="LXXLL motif 2"
FT   COMPBIAS        633..660
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        785..804
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        831..868
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        922..945
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        984..1010
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1011..1041
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1059..1111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1117..1194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1211..1295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1344..1361
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1419..1488
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1506..1521
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1528..1549
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1570 AA;  165682 MW;  B93DDDEEC5E2040F CRC64;
     MSSLLERLHS KYSQNRPWPE TIKLVRQIME KRTGMMSGSH QHLVTCLETL QKALKVSSLS
     AMTDRLESIA RQNGLTSHLS PNGTECYITT DMFYLEVLLD TEGQLCDVKV AHHRENPVSC
     PELVEQLREK NFEDFSQHLK GLVNLYKVPG DNKLETKMYL ALQSLELDLT KMAAIYWQAT
     NATVLEKILH GTVGYLTPRS GGQVMSLKYY VSPYDLFDDG TGASISLSEG HAVPRSLGMN
     VSVTIEATTS MYKLPIAPLI VGSHAMDNKG TPSFTSITNA NSVDLPACFF LKFPQPIPVS
     RAFIQKIEHC TGIPLIDGSH TFLPHYELVT QFELAKEKDP GPLNHNMRFY ASLPGQQHCY
     FLNKDAPLPD GRSLQGTLLS KIPFQHPSRV PVILSLIRHQ VAYNTLIGSC VKRTMLKEDC
     PGLLQFEVAP LSDSCFSISF QHPVNDSLVC VVMDVQDSTH VSCKLYKGLS DALICTDDFI
     TKVVQRCMSI PVTMRAIRRK AETIQADTPA LSLIAETVED MVKKNLPPAS SPGYGMTSAL
     SGLTTPTSSY TSGQNSSLFN MGMKERHDST GHGDDFNKVT QNPILTSLLQ ITNNTGGTLG
     SSPTQPQHTP PPVSSPASNT KNHPMLMNLL KDNPAQDFSN LYGGSPMERQ NSSGSPRTEL
     GASATGKPKK KRPRTGAEKM KNQTEDDFQR ELFSMDVDSQ NTIFDVGMAG DALDTPHITP
     APSQCGTPPT VYQQSIPHAQ SNMQRMVRIP STDAIIPDVT DILSDIAEEA SKLSGPGEDC
     PNLGTPVRDS SSSGHSQSTL FDTDVFQVDG GGGSGGENPY PDPVDLIVDS HGSPNSDSPN
     TFFNSVDFNP DLLNSQSQSG FTDDLNDDSS QSGDNDFKDF AGPGLASLNI VSGLPVDGGD
     GKYKMGLGAD TLDFSIISTG GSKTLGGPDI QETQSRSQSP LLSNDLGKDR PQKQKVKESS
     NGGGAGGGLS GMQSAGMEGK SMKRSRTPSS DGKSKDKPPK RKKTESDGKS PSHITNRPFT
     PPTSTGGSKS PGTSGRSQTP PGMATPPIPK ITIQIPKGTV SVGKPSSHGQ YSSSGSSSSS
     SSKSHHGHSS LSSSASGKIK SNKSDGSSGM KIGSSGGGMY SGQSGQSSSQ SKNSSQSMGK
     AGSSPITKHG LSSNVSNSSG SKTKPQGKPS VLMNPSLSKP NISPSHSRPS GGSDKMSSPM
     KPMPGTPPSS KAKSPIGSGG QHLSGGGSNS TTKSSSGLVS SGSLSQKPNS SSSSSSSSSS
     SSSSSSSSSS SFCGGVSQNL HGNSKGKSPS RNKKPSLTAV IDKLKHGVGT GGPGSEDPMD
     GGGGGGSTGA PSHGMSSKHG MVVGEFPTKR EKSEKDKSKG SGSGGSSDPS KKGGGDSKGS
     VGTGVAKIII SKHDGGSPSI KAKVTLQKPE GGGDGLRSQM QKNYGSPLIS GSTPKHERCS
     PSHNKSPAYT PQALDSESES GSSSIAEKSY QNSPSSDDGG GSGSRAQTEY SAEKHKKHKK
     EKKRLKDKDR DREKKKSYGM KPESWSKSPI SADPTMAMSG GSMMSSDRGV RPTPSFLMDD
     DDLMDVPLTL