ID   MED20_ANOGA             Reviewed;         218 AA.
AC   Q7Q6Y4;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 6.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
GN   Name=MED20; ORFNames=AGAP005604;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; AAAB01008960; EAA11828.4; -; Genomic_DNA.
DR   RefSeq; XP_315616.4; XM_315616.4.
DR   AlphaFoldDB; Q7Q6Y4; -.
DR   SMR; Q7Q6Y4; -.
DR   STRING; 7165.AGAP005604-PA; -.
DR   PaxDb; Q7Q6Y4; -.
DR   GeneID; 1276291; -.
DR   KEGG; aga:AgaP_AGAP005604; -.
DR   CTD; 1276291; -.
DR   VEuPathDB; VectorBase:AGAP005604; -.
DR   eggNOG; KOG4309; Eukaryota.
DR   HOGENOM; CLU_080044_1_0_1; -.
DR   InParanoid; Q7Q6Y4; -.
DR   OMA; NDIYEPM; -.
DR   OrthoDB; 1112080at2759; -.
DR   PhylomeDB; Q7Q6Y4; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465; PTHR12465; 1.
DR   Pfam; PF08612; Med20; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..218
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308562"
SQ   SEQUENCE   218 AA;  24279 MW;  6398FB5CCD45FFAD CRC64;
     MGVTVLQPYP LEKSGAQTID FLLKRVVALG AVPAGQFLVD CETYSSNPQL GPPKTVHILH
     NSEQPASVFS ILDTGTKQIP LVTDGLFDLL MTRIAPAYTS KKQTKIESKG QRFEFGDFVI
     KLGSVTMSQN FKGVLVEVEY RPCLVPGSCW ELMREFLQGF LGSNVSNSMP AYFTQRSSIN
     PNHSKANEIY QPIDTINQYL EHFTNYRKQT MAPVGVRP