ID   MED20_CAEBR             Reviewed;         198 AA.
AC   Q61A42; A8XIZ8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
GN   Name=mdt-20; ORFNames=CBG13937;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601467; CAP32625.3; -; Genomic_DNA.
DR   RefSeq; XP_002634829.1; XM_002634783.1.
DR   AlphaFoldDB; Q61A42; -.
DR   SMR; Q61A42; -.
DR   STRING; 6238.CBG13937; -.
DR   EnsemblMetazoa; CBG13937.1; CBG13937.1; WBGene00034614.
DR   GeneID; 8576821; -.
DR   KEGG; cbr:CBG_13937; -.
DR   CTD; 8576821; -.
DR   WormBase; CBG13937; CBP09544; WBGene00034614; Cbr-mdt-20.
DR   eggNOG; KOG4309; Eukaryota.
DR   HOGENOM; CLU_1385324_0_0_1; -.
DR   InParanoid; Q61A42; -.
DR   OMA; QSTFSIC; -.
DR   OrthoDB; 1365623at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465; PTHR12465; 1.
DR   Pfam; PF08612; Med20; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..198
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308559"
SQ   SEQUENCE   198 AA;  22269 MW;  AF0B4F91453AEE9C CRC64;
     MGVSWVFEAE QTAKSVERIL EGIGAELMGQ FQVDVIPYNP ATPSTDYATN IVMHHSKCPQ
     STFSICPKTD FRVSPKAVCD RGFDLILGKL AGGLVIDNAG KIEINGNEYN IHSDWTVRVG
     TATQGTTVKG VVVEVEYDPT VIIVQCREMM AEFIKQVFNK YHETQPEIFK ITEKPERYST
     LDTMWQYLQI AAKLRKKT