ID   MED20_CAEEL             Reviewed;         198 AA.
AC   Q9N5A1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
GN   Name=mdt-20; ORFNames=Y104H12D.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; FO080911; CCD67728.1; -; Genomic_DNA.
DR   RefSeq; NP_500050.1; NM_067649.1.
DR   AlphaFoldDB; Q9N5A1; -.
DR   SMR; Q9N5A1; -.
DR   IntAct; Q9N5A1; 1.
DR   STRING; 6239.Y104H12D.1a; -.
DR   EPD; Q9N5A1; -.
DR   PaxDb; Q9N5A1; -.
DR   PeptideAtlas; Q9N5A1; -.
DR   EnsemblMetazoa; Y104H12D.1a.1; Y104H12D.1a.1; WBGene00007020.
DR   UCSC; Y104H12D.1; c. elegans.
DR   WormBase; Y104H12D.1a; CE28102; WBGene00007020; mdt-20.
DR   eggNOG; KOG4309; Eukaryota.
DR   HOGENOM; CLU_1385324_0_0_1; -.
DR   InParanoid; Q9N5A1; -.
DR   OMA; QSTFSIC; -.
DR   OrthoDB; 1365623at2759; -.
DR   PhylomeDB; Q9N5A1; -.
DR   PRO; PR:Q9N5A1; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00007020; Expressed in embryo and 3 other tissues.
DR   ExpressionAtlas; Q9N5A1; baseline and differential.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465; PTHR12465; 1.
DR   Pfam; PF08612; Med20; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..198
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308560"
SQ   SEQUENCE   198 AA;  22181 MW;  D97D5F91588C6848 CRC64;
     MGVTWVFEAE QTAKSVERLL ESIGGDLHGT FIVDVTPFNP PTPSSDYPSN VVMHHSKCPQ
     STFSICPKDT FKKSPKAVCD RGFDLILSKL SSGLIADNAG KIEIIGNEYS LYKDWMIRVG
     TATQGTTVKG VVVEIEYDPS IIVIQCKDMM IEFVKSVFNK YHETLPEIFK ITEKPESYTA
     LDTMWQYLGI ATKLRKKT