ID   MED20_CANGA             Reviewed;         215 AA.
AC   Q6FVZ8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
GN   Name=SRB2; Synonyms=MED20; OrderedLocusNames=CAGL0D04136g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380950; CAG58507.2; -; Genomic_DNA.
DR   RefSeq; XP_445596.2; XM_445596.2.
DR   AlphaFoldDB; Q6FVZ8; -.
DR   SMR; Q6FVZ8; -.
DR   STRING; 5478.XP_445596.2; -.
DR   EnsemblFungi; CAG58507; CAG58507; CAGL0D04136g.
DR   GeneID; 2887190; -.
DR   KEGG; cgr:CAGL0D04136g; -.
DR   CGD; CAL0128505; CAGL0D04136g.
DR   VEuPathDB; FungiDB:CAGL0D04136g; -.
DR   eggNOG; ENOG502RXMU; Eukaryota.
DR   HOGENOM; CLU_065844_1_0_1; -.
DR   InParanoid; Q6FVZ8; -.
DR   OMA; QRQSIKG; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0070847; C:core mediator complex; IEA:EnsemblFungi.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblFungi.
DR   GO; GO:0001094; F:TFIID-class transcription factor complex binding; IEA:EnsemblFungi.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR   GO; GO:0010689; P:negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus; IEA:EnsemblFungi.
DR   GO; GO:0010691; P:negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:EnsemblFungi.
DR   InterPro; IPR013921; Mediator_Med20.
DR   Pfam; PF08612; Med20; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..215
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308564"
SQ   SEQUENCE   215 AA;  23786 MW;  8473262AC90E0347 CRC64;
     MSSAVIFVES ATPGTLTEFK DLLAKQLLEV RETWSLEFRT YRTLVKDFPS REKLLYSLTF
     PHHDKKTVLI RNSLAWVLGT AEIPDNLQTC STGLSESIDQ LLASKLSNMW AQRQVIRGDA
     GQTLLITGDV TVRIINLFAA TGFKGLLIEL DNLQSATSLA NITDLLNEMK VKVFKVASAP
     GLKSEDVEVV DSSSTMESGN EALFTLAKQY IEVLE