ID   MED20_CHICK             Reviewed;         211 AA.
AC   Q5ZKY9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
DE   AltName: Full=TRF-proximal protein homolog;
GN   Name=MED20; Synonyms=TRFP; ORFNames=RCJMB04_8k10;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ719945; CAG31604.1; -; mRNA.
DR   RefSeq; NP_001006327.1; NM_001006327.2.
DR   AlphaFoldDB; Q5ZKY9; -.
DR   SMR; Q5ZKY9; -.
DR   STRING; 9031.ENSGALP00000005490; -.
DR   PaxDb; Q5ZKY9; -.
DR   Ensembl; ENSGALT00000005500; ENSGALP00000005490; ENSGALG00000003474.
DR   GeneID; 419926; -.
DR   KEGG; gga:419926; -.
DR   CTD; 9477; -.
DR   VEuPathDB; HostDB:geneid_419926; -.
DR   eggNOG; KOG4309; Eukaryota.
DR   GeneTree; ENSGT00390000002060; -.
DR   HOGENOM; CLU_080044_1_0_1; -.
DR   InParanoid; Q5ZKY9; -.
DR   OMA; QSTFSIC; -.
DR   OrthoDB; 1112080at2759; -.
DR   PhylomeDB; Q5ZKY9; -.
DR   TreeFam; TF315156; -.
DR   Reactome; R-GGA-212436; Generic Transcription Pathway.
DR   PRO; PR:Q5ZKY9; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000003474; Expressed in heart and 12 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465; PTHR12465; 1.
DR   Pfam; PF08612; Med20; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..211
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308556"
SQ   SEQUENCE   211 AA;  23289 MW;  34FC6DE6EFF16756 CRC64;
     MGVTCVTQVP VLEGKSVQQT VELLSKKLEL LGAEKHGAFG VDCETYHTAA AISSQGQTGK
     LMYVMHNSEY PLSCFALFEN GPCLIADANF DTLMVKLKGF FQNAKANKIE SRGTRYQYCD
     FLVKVGTVTM GPSARGISVE VEYCPCVIAN DCWNLLMEFM QSFMGSHTPG IPSVFGTKHD
     SIYSPADTMV QYMELFNKIR KQQQVPVAGI R