ID   MED20_DANRE             Reviewed;         212 AA.
AC   Q6DBX1; Q1MTK2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
DE   AltName: Full=TRF-proximal protein homolog;
GN   Name=med20; Synonyms=trfp; ORFNames=si:rp71-11b17.6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK03596.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL645789; CAK03596.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC078327; AAH78327.1; -; mRNA.
DR   RefSeq; NP_001003585.1; NM_001003585.1.
DR   AlphaFoldDB; Q6DBX1; -.
DR   SMR; Q6DBX1; -.
DR   STRING; 7955.ENSDARP00000067637; -.
DR   PaxDb; Q6DBX1; -.
DR   Ensembl; ENSDART00000189725; ENSDARP00000146689; ENSDARG00000046006.
DR   GeneID; 445191; -.
DR   KEGG; dre:445191; -.
DR   CTD; 9477; -.
DR   ZFIN; ZDB-GENE-040801-104; med20.
DR   eggNOG; KOG4309; Eukaryota.
DR   GeneTree; ENSGT00390000002060; -.
DR   HOGENOM; CLU_080044_1_0_1; -.
DR   InParanoid; Q6DBX1; -.
DR   OMA; QSTFSIC; -.
DR   OrthoDB; 1112080at2759; -.
DR   PhylomeDB; Q6DBX1; -.
DR   TreeFam; TF315156; -.
DR   Reactome; R-DRE-212436; Generic Transcription Pathway.
DR   PRO; PR:Q6DBX1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000046006; Expressed in mature ovarian follicle and 27 other tissues.
DR   ExpressionAtlas; Q6DBX1; baseline.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR013921; Mediator_Med20.
DR   PANTHER; PTHR12465; PTHR12465; 1.
DR   Pfam; PF08612; Med20; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..212
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308557"
SQ   SEQUENCE   212 AA;  23318 MW;  F3DA55D2890F4509 CRC64;
     MGVTCVCQVP VAEGKSVQQT VDLLHRKLEQ LGAVKQGNFW VDCETYHATG NATGQPSKLL
     YVMHNSEAPL SCMALFEGGP GLSADANFDV LMIKLKSHFQ NAKGHKVESR GTRYRYCDFL
     VKIGTVAMSS SARGISVEVE YCACVIPGDC WNLMKEFMQS FLGSNTPELP TVFTNKAEGL
     YVPVDCMDTM SQYLELFSKV RKQQVLPGSG VR