ID   MED20_DEBHA             Reviewed;         236 AA.
AC   Q6BXG1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20;
DE   AltName: Full=Mediator complex subunit 20;
GN   Name=SRB2; Synonyms=MED20; OrderedLocusNames=DEHA2B03300g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382134; CAG85099.2; -; Genomic_DNA.
DR   RefSeq; XP_457108.2; XM_457108.1.
DR   AlphaFoldDB; Q6BXG1; -.
DR   SMR; Q6BXG1; -.
DR   STRING; 4959.XP_457108.2; -.
DR   EnsemblFungi; CAG85099; CAG85099; DEHA2B03300g.
DR   GeneID; 2913123; -.
DR   KEGG; dha:DEHA2B03300g; -.
DR   VEuPathDB; FungiDB:DEHA2B03300g; -.
DR   eggNOG; ENOG502RXMU; Eukaryota.
DR   HOGENOM; CLU_065844_0_0_1; -.
DR   InParanoid; Q6BXG1; -.
DR   OMA; QRQSIKG; -.
DR   OrthoDB; 1112080at2759; -.
DR   Proteomes; UP000000599; Chromosome B.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR016532; Med20.
DR   InterPro; IPR013921; Mediator_Med20.
DR   Pfam; PF08612; Med20; 1.
DR   PIRSF; PIRSF007945; SRB2; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..236
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   20"
FT                   /id="PRO_0000308565"
SQ   SEQUENCE   236 AA;  26425 MW;  F86257F0C77024AF CRC64;
     MVSALILIQK ATPETIVQFH DQLSNELPTL KGKWSFSFKI FRNNPYSIAP ELAETSVTSS
     ESKFLYTLAP SYLVGSCISL INKNSACVFS NVIEEESAEI SNGSEFSIPD SHLHQGATTG
     LNDTFDFFVN QKMQSLWTQK QNIKGDGGQI YELENGSLII RTSNVFLHGI FKGLLIQIEV
     ENESSEHETS SLSEPFERVL SKYNIPRGKM SCNVLDSKLL DKYGDLCLQY SEILNF