MED21_ASPCL
ID MED21_ASPCL Reviewed; 189 AA.
AC A1C712;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE AltName: Full=Mediator complex subunit 21;
GN Name=srb7; Synonyms=med21; ORFNames=ACLA_072160;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC {ECO:0000305}.
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DR EMBL; DS027045; EAW14183.1; -; Genomic_DNA.
DR RefSeq; XP_001275609.1; XM_001275608.1.
DR AlphaFoldDB; A1C712; -.
DR SMR; A1C712; -.
DR STRING; 5057.CADACLAP00006905; -.
DR EnsemblFungi; EAW14183; EAW14183; ACLA_072160.
DR GeneID; 4708121; -.
DR KEGG; act:ACLA_072160; -.
DR VEuPathDB; FungiDB:ACLA_072160; -.
DR eggNOG; KOG1510; Eukaryota.
DR HOGENOM; CLU_094271_0_1_1; -.
DR OMA; DKNHDFE; -.
DR OrthoDB; 1583203at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR InterPro; IPR037212; Med7/Med21-like.
DR InterPro; IPR021384; Mediator_Med21.
DR PANTHER; PTHR13381; PTHR13381; 1.
DR Pfam; PF11221; Med21; 1.
DR SUPFAM; SSF140718; SSF140718; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..189
FT /note="Mediator of RNA polymerase II transcription subunit
FT 21"
FT /id="PRO_0000305956"
FT REGION 50..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 127..170
FT /evidence="ECO:0000255"
FT COMPBIAS 58..74
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 189 AA; 20568 MW; 443C151832964CFE CRC64;
MADILTQLQT CLDQLATQFY ATIGYLSTYH DNSPATTPTN IPNAAPALAK IPKNSTAPPV
PAGAPVPSQS SPPPPQTQRG ASEAAADPNL PPAPDSPRTF ASRQRELARD LIIKEQQIEY
LISVLPGIDS SEAEQEKRIR ELEAELRGVE EEREAKIREL RTLGRTLERV MGAVETGIYG
DRAVLERDS
