ID   MED21_BOVIN             Reviewed;         144 AA.
AC   Q2TBU8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE   AltName: Full=Mediator complex subunit 21;
DE   AltName: Full=RNA polymerase II holoenzyme component SRB7;
DE            Short=RNAPII complex component SRB7;
GN   Name=MED21; Synonyms=SURB7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with PPARG.
CC       Interacts with THRA in a ligand-dependent fashion (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC       {ECO:0000305}.
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DR   EMBL; BC109636; AAI09637.1; -; mRNA.
DR   RefSeq; NP_001033655.1; NM_001038566.1.
DR   AlphaFoldDB; Q2TBU8; -.
DR   SMR; Q2TBU8; -.
DR   STRING; 9913.ENSBTAP00000006696; -.
DR   PaxDb; Q2TBU8; -.
DR   Ensembl; ENSBTAT00000006696; ENSBTAP00000006696; ENSBTAG00000005082.
DR   GeneID; 539496; -.
DR   KEGG; bta:539496; -.
DR   CTD; 9412; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005082; -.
DR   VGNC; VGNC:31358; MED21.
DR   eggNOG; KOG1510; Eukaryota.
DR   GeneTree; ENSGT00390000014557; -.
DR   HOGENOM; CLU_126757_0_0_1; -.
DR   InParanoid; Q2TBU8; -.
DR   OMA; QAENFCN; -.
DR   OrthoDB; 1583203at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000005082; Expressed in oocyte and 109 other tissues.
DR   ExpressionAtlas; Q2TBU8; baseline and differential.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR021384; Mediator_Med21.
DR   PANTHER; PTHR13381; PTHR13381; 1.
DR   Pfam; PF11221; Med21; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..144
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   21"
FT                   /id="PRO_0000305945"
SQ   SEQUENCE   144 AA;  15521 MW;  CCFEA08E5B7C63AC CRC64;
     MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFSNIQT AINKDQPANP TEEYAQLFAA
     LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA ATSLEDVVYR GDMLLEKIQS
     ALADIAQSQL KTRSGTHSQS LPDS