ID   MED21_CAEEL             Reviewed;         130 AA.
AC   Q6BER6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE   AltName: Full=CeSRB7;
DE   AltName: Full=Mediator complex subunit 21;
GN   Name=mdt-21; ORFNames=C24H11.9;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   INTERACTION WITH LET-49.
RX   PubMed=10611325; DOI=10.1073/pnas.96.26.14990;
RA   Kwon J.Y., Park J.M., Gim B.S., Han S.J., Lee J., Kim Y.-J.;
RT   "Caenorhabditis elegans mediator complexes are required for developmental-
RT   specific transcriptional activation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:14990-14995(1999).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex (By similarity). Interacts
CC       with let49/mdt-7. {ECO:0000250, ECO:0000269|PubMed:10611325}.
CC   -!- INTERACTION:
CC       Q6BER6; Q95Q17: let-49; NbExp=2; IntAct=EBI-1533858, EBI-1533863;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC       {ECO:0000305}.
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DR   EMBL; Z81475; CAH04698.1; -; Genomic_DNA.
DR   RefSeq; NP_001021184.1; NM_001026013.1.
DR   AlphaFoldDB; Q6BER6; -.
DR   SMR; Q6BER6; -.
DR   BioGRID; 532890; 1.
DR   IntAct; Q6BER6; 5.
DR   STRING; 6239.C24H11.9; -.
DR   EPD; Q6BER6; -.
DR   PaxDb; Q6BER6; -.
DR   PeptideAtlas; Q6BER6; -.
DR   EnsemblMetazoa; C24H11.9.1; C24H11.9.1; WBGene00007704.
DR   GeneID; 3565572; -.
DR   KEGG; cel:CELE_C24H11.9; -.
DR   UCSC; C24H11.9; c. elegans.
DR   CTD; 3565572; -.
DR   WormBase; C24H11.9; CE36687; WBGene00007704; mdt-21.
DR   eggNOG; KOG1510; Eukaryota.
DR   GeneTree; ENSGT00390000014557; -.
DR   HOGENOM; CLU_126757_0_0_1; -.
DR   InParanoid; Q6BER6; -.
DR   OMA; TAPPCEF; -.
DR   OrthoDB; 1583203at2759; -.
DR   PhylomeDB; Q6BER6; -.
DR   PRO; PR:Q6BER6; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007704; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR021384; Mediator_Med21.
DR   PANTHER; PTHR13381; PTHR13381; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   1: Evidence at protein level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..130
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   21"
FT                   /id="PRO_0000305951"
FT   COILED          71..99
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  14135 MW;  1308EACEAD197C4B CRC64;
     MADRMTQLQD MINEMAGLMT NAIGVLQATA PPCEFGAISQ ELEDEPNCAI FAAGIAKAAK
     NIEILIDSFP IEAGNQEAEV EEKMIKNDEK QREKVNELVG LVGDSNRLVG VVQKKLAEIS
     KTQMSSRPSE