ID   MED21_DEBHA             Reviewed;         173 AA.
AC   Q6BQ63;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE   AltName: Full=Mediator complex subunit 21;
GN   Name=SRB7; Synonyms=MED21; OrderedLocusNames=DEHA2E08008g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382137; CAG87890.1; -; Genomic_DNA.
DR   RefSeq; XP_459657.1; XM_459657.1.
DR   AlphaFoldDB; Q6BQ63; -.
DR   SMR; Q6BQ63; -.
DR   STRING; 4959.XP_459657.1; -.
DR   EnsemblFungi; CAG87890; CAG87890; DEHA2E08008g.
DR   GeneID; 2902805; -.
DR   KEGG; dha:DEHA2E08008g; -.
DR   VEuPathDB; FungiDB:DEHA2E08008g; -.
DR   eggNOG; KOG1510; Eukaryota.
DR   HOGENOM; CLU_094271_0_1_1; -.
DR   InParanoid; Q6BQ63; -.
DR   OMA; DKNHDFE; -.
DR   OrthoDB; 1583203at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR021384; Mediator_Med21.
DR   PANTHER; PTHR13381; PTHR13381; 1.
DR   Pfam; PF11221; Med21; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..173
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   21"
FT                   /id="PRO_0000305963"
FT   REGION          30..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          123..155
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  18786 MW;  903F45B635E3FB21 CRC64;
     MTDRLTQLQV CLDQLVEQFN ATVNYVNTNS EPGLLDEDPS SVSNLAANAP IPGVQQQPSQ
     GSGGGSNKQT NAGNSVSNQP SAKAEAESNF ENTINELSTD IILKSRQITM LIDSLPGIGV
     SPESQLNMVE DLAKQLEEVE KERIKKIEEK DKLLKWCESL IVEVATGISE SRE