ID   MED21_NEUCR             Reviewed;         137 AA.
AC   Q7S8C2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE   AltName: Full=Mediator complex subunit 21;
GN   Name=srb-7; Synonyms=med-21; ORFNames=NCU05263;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC       {ECO:0000305}.
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DR   EMBL; CM002239; EAA32592.1; -; Genomic_DNA.
DR   RefSeq; XP_961828.1; XM_956735.2.
DR   AlphaFoldDB; Q7S8C2; -.
DR   SMR; Q7S8C2; -.
DR   STRING; 5141.EFNCRP00000004973; -.
DR   EnsemblFungi; EAA32592; EAA32592; NCU05263.
DR   GeneID; 3877976; -.
DR   KEGG; ncr:NCU05263; -.
DR   VEuPathDB; FungiDB:NCU05263; -.
DR   HOGENOM; CLU_094271_1_1_1; -.
DR   InParanoid; Q7S8C2; -.
DR   OMA; DKNHDFE; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR021384; Mediator_Med21.
DR   PANTHER; PTHR13381; PTHR13381; 1.
DR   Pfam; PF11221; Med21; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..137
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   21"
FT                   /id="PRO_0000305967"
FT   REGION          37..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          87..130
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   137 AA;  15930 MW;  0BD55094781BA6A6 CRC64;
     MSDRLSQLQE AVDQLMEQFI ATYFYIDRHH DLKTFSPKDT IAPSKADQPP EVDTLPPDVF
     QAGQLELARD LITREQQIEY LISSLPGLDN SEQDQLQSIK ELEEELNVAE KQRQEAVKEK
     DEVLVKLDQT LRSIRRY