ID   MED21_PICST             Reviewed;         164 AA.
AC   A3LS24;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 21;
DE   AltName: Full=Mediator complex subunit 21;
GN   Name=SRB7; Synonyms=MED21; ORFNames=PICST_30897;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 21 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000497; ABN65489.1; -; Genomic_DNA.
DR   RefSeq; XP_001383518.1; XM_001383481.1.
DR   AlphaFoldDB; A3LS24; -.
DR   SMR; A3LS24; -.
DR   STRING; 4924.XP_001383518.1; -.
DR   EnsemblFungi; ABN65489; ABN65489; PICST_30897.
DR   GeneID; 4838115; -.
DR   KEGG; pic:PICST_30897; -.
DR   eggNOG; KOG1510; Eukaryota.
DR   HOGENOM; CLU_094271_0_1_1; -.
DR   InParanoid; A3LS24; -.
DR   OMA; DKNHDFE; -.
DR   OrthoDB; 1583203at2759; -.
DR   Proteomes; UP000002258; Chromosome 3.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR021384; Mediator_Med21.
DR   PANTHER; PTHR13381; PTHR13381; 1.
DR   Pfam; PF11221; Med21; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   3: Inferred from homology;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..164
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   21"
FT                   /id="PRO_0000305969"
FT   REGION          49..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          114..146
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  17987 MW;  34E1D9DA841E5875 CRC64;
     MADRLTQLQT CLDQLVEQFN ATVNYINTSS EPSLLDEDPT SVSNIAASAP LPANQTQQGS
     TLGSNRQTVS PSTQAEAESN FENTINELST DIILKSRQIS MLIDSLPGIG VSPESQLKII
     DDLSKELQSV EQEQVKKIQE KDKLLKWCES LIVEVATGIS ETRH