ID   MED22_CAEBR             Reviewed;         153 AA.
AC   Q626S1; A8WPG7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 22;
DE   AltName: Full=Mediator complex subunit 22;
GN   Name=mdt-22; ORFNames=CBG00854;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 22 family.
CC       {ECO:0000305}.
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DR   EMBL; HE600951; CAP22374.1; -; Genomic_DNA.
DR   RefSeq; XP_002629649.1; XM_002629603.1.
DR   AlphaFoldDB; Q626S1; -.
DR   SMR; Q626S1; -.
DR   STRING; 6238.CBG00854; -.
DR   EnsemblMetazoa; CBG00854.1; CBG00854.1; WBGene00024183.
DR   GeneID; 8573053; -.
DR   KEGG; cbr:CBG_00854; -.
DR   CTD; 8573053; -.
DR   WormBase; CBG00854; CBP05921; WBGene00024183; Cbr-mdt-22.
DR   eggNOG; KOG3304; Eukaryota.
DR   HOGENOM; CLU_117242_2_0_1; -.
DR   InParanoid; Q626S1; -.
DR   OMA; ILRYDAM; -.
DR   OrthoDB; 1573728at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009332; Med22.
DR   PANTHER; PTHR12434; PTHR12434; 1.
DR   Pfam; PF06179; Med22; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..153
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   22"
FT                   /id="PRO_0000308571"
SQ   SEQUENCE   153 AA;  17743 MW;  DD495774E41A27AF CRC64;
     MSGNAQKKAA SRSMATKKLI IDEFKRRLRD NIKSLNDNFY HIIQAAKVNP DDNAFKNQTG
     KMTEFYTIKN EMAVRAQLMV RASDELLRLT TDLKEFLILH DFHFLTHNIK QAESQCEDTL
     RQQSHLHQAL DTDVSNMLFA LEEEIADNFF LGH