ID   MED22_CAEEL             Reviewed;         157 AA.
AC   Q23679;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 22;
DE   AltName: Full=Mediator complex subunit 22;
GN   Name=mdt-22; ORFNames=ZK970.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15175151; DOI=10.1016/j.molcel.2004.05.011;
RA   Bourbon H.-M., Aguilera A., Ansari A.Z., Asturias F.J., Berk A.J.,
RA   Bjoerklund S., Blackwell T.K., Borggrefe T., Carey M., Carlson M.,
RA   Conaway J.W., Conaway R.C., Emmons S.W., Fondell J.D., Freedman L.P.,
RA   Fukasawa T., Gustafsson C.M., Han M., He X., Herman P.K., Hinnebusch A.G.,
RA   Holmberg S., Holstege F.C.P., Jaehning J.A., Kim Y.-J., Kuras L., Leutz A.,
RA   Lis J.T., Meisterernest M., Naeaer A.M., Nasmyth K., Parvin J.D.,
RA   Ptashne M., Reinberg D., Ronne H., Sadowski I., Sakurai H., Sipiczki M.,
RA   Sternberg P.W., Stillman D.J., Strich R., Struhl K., Svejstrup J.Q.,
RA   Tuck S., Winston F., Roeder R.G., Kornberg R.D.;
RT   "A unified nomenclature for protein subunits of mediator complexes linking
RT   transcriptional regulators to RNA polymerase II.";
RL   Mol. Cell 14:553-557(2004).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 22 family.
CC       {ECO:0000305}.
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DR   EMBL; BX284602; CAA88887.1; -; Genomic_DNA.
DR   PIR; T28127; T28127.
DR   RefSeq; NP_496216.1; NM_063815.4.
DR   AlphaFoldDB; Q23679; -.
DR   SMR; Q23679; -.
DR   BioGRID; 39914; 3.
DR   DIP; DIP-26478N; -.
DR   IntAct; Q23679; 3.
DR   STRING; 6239.ZK970.3; -.
DR   EPD; Q23679; -.
DR   PaxDb; Q23679; -.
DR   PeptideAtlas; Q23679; -.
DR   EnsemblMetazoa; ZK970.3.1; ZK970.3.1; WBGene00007022.
DR   GeneID; 174595; -.
DR   KEGG; cel:CELE_ZK970.3; -.
DR   UCSC; ZK970.3; c. elegans.
DR   CTD; 174595; -.
DR   WormBase; ZK970.3; CE02403; WBGene00007022; mdt-22.
DR   eggNOG; KOG3304; Eukaryota.
DR   GeneTree; ENSGT00390000004339; -.
DR   HOGENOM; CLU_117242_2_0_1; -.
DR   InParanoid; Q23679; -.
DR   OMA; ILRYDAM; -.
DR   OrthoDB; 1573728at2759; -.
DR   PhylomeDB; Q23679; -.
DR   PRO; PR:Q23679; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00007022; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009332; Med22.
DR   PANTHER; PTHR12434; PTHR12434; 1.
DR   Pfam; PF06179; Med22; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..157
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   22"
FT                   /id="PRO_0000178841"
SQ   SEQUENCE   157 AA;  18163 MW;  72AC932B959A77C3 CRC64;
     MSGVAGGASK KSSSRTMATK KLIIDEFKRR LRDNIKSLND NFFHIIQAAK VNPDDNAYKN
     QTGKMTEFYT TKNEMAVRAQ LMVRASDELL KLTADLKEFL ILHDFHFLTH NIKQAEAQCE
     ETLRQQSHQH NCLDSEVSNI LFDLEREIAE NFYLRHT