ARH37_HUMAN
ID ARH37_HUMAN Reviewed; 675 AA.
AC A1IGU5; Q6ZW51;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Rho guanine nucleotide exchange factor 37;
GN Name=ARHGEF37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yamazaki N.;
RT "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and
RT human.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-675, AND VARIANTS LEU-489 AND
RP VAL-604.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May act as a guanine nucleotide exchange factor (GEF).
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC85655.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB199796; BAF43710.1; -; mRNA.
DR EMBL; AK123597; BAC85655.1; ALT_INIT; mRNA.
DR CCDS; CCDS43385.1; -.
DR RefSeq; NP_001001669.2; NM_001001669.2.
DR RefSeq; XP_005268504.1; XM_005268447.4.
DR RefSeq; XP_006714847.1; XM_006714784.3.
DR AlphaFoldDB; A1IGU5; -.
DR SMR; A1IGU5; -.
DR BioGRID; 133100; 4.
DR IntAct; A1IGU5; 1.
DR STRING; 9606.ENSP00000328083; -.
DR iPTMnet; A1IGU5; -.
DR PhosphoSitePlus; A1IGU5; -.
DR BioMuta; ARHGEF37; -.
DR EPD; A1IGU5; -.
DR jPOST; A1IGU5; -.
DR MassIVE; A1IGU5; -.
DR MaxQB; A1IGU5; -.
DR PaxDb; A1IGU5; -.
DR PeptideAtlas; A1IGU5; -.
DR PRIDE; A1IGU5; -.
DR ProteomicsDB; 123; -.
DR Antibodypedia; 71502; 20 antibodies from 9 providers.
DR DNASU; 389337; -.
DR Ensembl; ENST00000333677.7; ENSP00000328083.6; ENSG00000183111.12.
DR GeneID; 389337; -.
DR KEGG; hsa:389337; -.
DR MANE-Select; ENST00000333677.7; ENSP00000328083.6; NM_001001669.3; NP_001001669.2.
DR UCSC; uc003lra.2; human.
DR CTD; 389337; -.
DR GeneCards; ARHGEF37; -.
DR HGNC; HGNC:34430; ARHGEF37.
DR HPA; ENSG00000183111; Low tissue specificity.
DR neXtProt; NX_A1IGU5; -.
DR OpenTargets; ENSG00000183111; -.
DR PharmGKB; PA165660135; -.
DR VEuPathDB; HostDB:ENSG00000183111; -.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00950000183088; -.
DR HOGENOM; CLU_005159_0_0_1; -.
DR InParanoid; A1IGU5; -.
DR OMA; FLCFRPH; -.
DR OrthoDB; 207472at2759; -.
DR PhylomeDB; A1IGU5; -.
DR TreeFam; TF330015; -.
DR PathwayCommons; A1IGU5; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR SignaLink; A1IGU5; -.
DR BioGRID-ORCS; 389337; 13 hits in 1070 CRISPR screens.
DR ChiTaRS; ARHGEF37; human.
DR GenomeRNAi; 389337; -.
DR Pharos; A1IGU5; Tdark.
DR PRO; PR:A1IGU5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; A1IGU5; protein.
DR Bgee; ENSG00000183111; Expressed in parotid gland and 183 other tissues.
DR ExpressionAtlas; A1IGU5; baseline and differential.
DR Genevisible; A1IGU5; HS.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR CDD; cd11941; SH3_ARHGEF37_C2; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035636; ARHGEF37_SH3_2.
DR InterPro; IPR035823; ARHGEF37_SH3_C1.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50044; SSF50044; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor; Reference proteome; Repeat;
KW SH3 domain.
FT CHAIN 1..675
FT /note="Rho guanine nucleotide exchange factor 37"
FT /id="PRO_0000337050"
FT DOMAIN 30..213
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 254..455
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT DOMAIN 506..569
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 602..665
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 421
FT /note="M -> L (in dbSNP:rs4629585)"
FT /id="VAR_043579"
FT VARIANT 489
FT /note="P -> L (in dbSNP:rs9324624)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043580"
FT VARIANT 518
FT /note="S -> R (in dbSNP:rs7732714)"
FT /id="VAR_043581"
FT VARIANT 586
FT /note="P -> T (in dbSNP:rs3733662)"
FT /id="VAR_043582"
FT VARIANT 604
FT /note="M -> V (in dbSNP:rs1135093)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043583"
SQ SEQUENCE 675 AA; 76278 MW; 90EC3F5B7BFA7178 CRC64;
MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL
QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV
YCASYDQALL LVDTYRKEPE LQRHIQGIVE AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ
KILENTVPDA SAYPVLQRAV SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT
HTLSKKTTRL SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF
LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL AKALLGPQNL
IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS LLVAELPQFN QLVMQWLGQI
MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH VPEPAFRKLV EDALGRTSNQ LRSFQETFEK
VQPPPTTQPL LPGSERQVQA LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD
TKGNSGRWLV DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS
IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG QRGYVPSGFL
ARARSPVLWG WSLPS
