ID   MED22_CHICK             Reviewed;         203 AA.
AC   Q800L3; Q800L2;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 22;
DE   AltName: Full=Mediator complex subunit 22;
DE   AltName: Full=Surfeit locus protein 5;
GN   Name=MED22; Synonyms=SURF5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000312|EMBL:BAC65167.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   TISSUE=Liver {ECO:0000312|EMBL:BAC65167.1};
RA   Maeda N., Toku S., Kenmochi N., Tanaka T.;
RT   "The gene cluster containing ribosomal protein L7a gene of the chicken.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|Ref.1}; Synonyms=Surf5B;
CC         IsoId=Q800L3-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|Ref.1}; Synonyms=Surf5A;
CC         IsoId=Q800L3-2; Sequence=VSP_052316, VSP_052317;
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 22 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB050009; BAC65167.1; -; Genomic_DNA.
DR   EMBL; AB050009; BAC65168.1; -; Genomic_DNA.
DR   RefSeq; NP_001039295.1; NM_001045830.1. [Q800L3-2]
DR   RefSeq; XP_015134928.1; XM_015279442.1. [Q800L3-1]
DR   AlphaFoldDB; Q800L3; -.
DR   SMR; Q800L3; -.
DR   STRING; 9031.ENSGALP00000005067; -.
DR   PaxDb; Q800L3; -.
DR   Ensembl; ENSGALT00000005076; ENSGALP00000005067; ENSGALG00000003204. [Q800L3-1]
DR   GeneID; 417159; -.
DR   KEGG; gga:417159; -.
DR   CTD; 6837; -.
DR   VEuPathDB; HostDB:geneid_417159; -.
DR   eggNOG; KOG3304; Eukaryota.
DR   GeneTree; ENSGT00390000004339; -.
DR   HOGENOM; CLU_117242_0_0_1; -.
DR   InParanoid; Q800L3; -.
DR   OMA; TQCEQDT; -.
DR   OrthoDB; 1573728at2759; -.
DR   PhylomeDB; Q800L3; -.
DR   TreeFam; TF323390; -.
DR   PRO; PR:Q800L3; -.
DR   Proteomes; UP000000539; Chromosome 17.
DR   Bgee; ENSGALG00000003204; Expressed in spleen and 13 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009332; Med22.
DR   PANTHER; PTHR12434; PTHR12434; 1.
DR   Pfam; PF06179; Med22; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..203
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   22"
FT                   /id="PRO_0000278123"
FT   REGION          164..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          93..123
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        165..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         138..140
FT                   /note="SYS -> RYK (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_052316"
FT   VAR_SEQ         141..203
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_052317"
SQ   SEQUENCE   203 AA;  23049 MW;  1110916804B0C549 CRC64;
     MAQQRVLPQS KETLLQSYNK RLKDDVKSIM DNFTEIIKTA KIEDETQVSR ATQSEQDNYE
     MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAINQ RNQQLRSLQE ECDKKLIALR
     DEISIDLYEL EEEYYSSSYS LCDSNDLPLC EAYWREDFDM PSPESLSMPL TTATAEQSIA
     TSQSSTPSHP HVNGHGAGPT DHS