ARH37_MOUSE
ID ARH37_MOUSE Reviewed; 676 AA.
AC A1IGU4; Q8C0M3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Rho guanine nucleotide exchange factor 37;
GN Name=Arhgef37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=ddY;
RA Yamazaki N.;
RT "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and
RT human.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May act as a guanine nucleotide exchange factor (GEF).
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1IGU4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1IGU4-2; Sequence=VSP_033856;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB199795; BAF43709.1; -; mRNA.
DR EMBL; AK030242; BAC26861.1; -; mRNA.
DR CCDS; CCDS50302.1; -. [A1IGU4-1]
DR RefSeq; NP_808496.2; NM_177828.4.
DR AlphaFoldDB; A1IGU4; -.
DR SMR; A1IGU4; -.
DR STRING; 10090.ENSMUSP00000130560; -.
DR iPTMnet; A1IGU4; -.
DR PhosphoSitePlus; A1IGU4; -.
DR MaxQB; A1IGU4; -.
DR PaxDb; A1IGU4; -.
DR PeptideAtlas; A1IGU4; -.
DR PRIDE; A1IGU4; -.
DR ProteomicsDB; 283200; -. [A1IGU4-1]
DR ProteomicsDB; 283201; -. [A1IGU4-2]
DR Antibodypedia; 71502; 20 antibodies from 9 providers.
DR DNASU; 328967; -.
DR Ensembl; ENSMUST00000236608; ENSMUSP00000157463; ENSMUSG00000045094. [A1IGU4-2]
DR GeneID; 328967; -.
DR KEGG; mmu:328967; -.
DR CTD; 389337; -.
DR MGI; MGI:3045339; Arhgef37.
DR VEuPathDB; HostDB:ENSMUSG00000045094; -.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00950000183088; -.
DR InParanoid; A1IGU4; -.
DR OrthoDB; 207472at2759; -.
DR PhylomeDB; A1IGU4; -.
DR Reactome; R-MMU-193648; NRAGE signals death through JNK.
DR Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR BioGRID-ORCS; 328967; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Arhgef37; mouse.
DR PRO; PR:A1IGU4; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; A1IGU4; protein.
DR Bgee; ENSMUSG00000045094; Expressed in tail skin and 121 other tissues.
DR ExpressionAtlas; A1IGU4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR CDD; cd11941; SH3_ARHGEF37_C2; 1.
DR Gene3D; 1.20.1270.60; -; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035636; ARHGEF37_SH3_2.
DR InterPro; IPR035823; ARHGEF37_SH3_C1.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50044; SSF50044; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Guanine-nucleotide releasing factor;
KW Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..676
FT /note="Rho guanine nucleotide exchange factor 37"
FT /id="PRO_0000337051"
FT DOMAIN 30..213
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 254..455
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT DOMAIN 506..569
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 603..666
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..153
FT /note="MADFGADEASSKSESPEQEDQGSEDRSLLHQRLAIRELIDTEVSYLHTLRLC
FT ASDIRSHLQQLPPGDLDILFSNIDDIIQVSSRFLRGLQETACREEEQAHLIGNLFLEFQ
FT EEFEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAM -> MVSTCLTATFSLR
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033856"
SQ SEQUENCE 676 AA; 76524 MW; 6D9BD8BE17F4912D CRC64;
MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR LCASDIRSHL
QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA HLIGNLFLEF QEEFEQVYKV
YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ
KILENTPADA SAHPALQRAT SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT
HTLSKKTTRL SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF
LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL ARALAGPQNL
IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS LLVAELPQFN QLVMQWLGQI
LCTFVVLQRD LADQVLRRAE STMALLPHHH VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK
VLPPSTTQPL LPGSEHQMQA LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD
TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF
LARTPSPTPW GWNLPS
