ID   MED22_XENLA             Reviewed;         201 AA.
AC   Q6GQ95;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 22;
DE   AltName: Full=Mediator complex subunit 22;
DE   AltName: Full=Surfeit locus protein 5;
GN   Name=med22; Synonyms=surf5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 22 family.
CC       {ECO:0000305}.
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DR   EMBL; BC072852; AAH72852.1; -; mRNA.
DR   RefSeq; NP_001085498.1; NM_001092029.1.
DR   AlphaFoldDB; Q6GQ95; -.
DR   SMR; Q6GQ95; -.
DR   MaxQB; Q6GQ95; -.
DR   DNASU; 443924; -.
DR   GeneID; 443924; -.
DR   KEGG; xla:443924; -.
DR   CTD; 443924; -.
DR   Xenbase; XB-GENE-959340; med22.L.
DR   OMA; TQCEQDT; -.
DR   OrthoDB; 1573728at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 443924; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009332; Med22.
DR   PANTHER; PTHR12434; PTHR12434; 1.
DR   Pfam; PF06179; Med22; 1.
PE   2: Evidence at transcript level;
KW   Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..201
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   22"
FT                   /id="PRO_0000308570"
FT   REGION          182..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          93..123
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  22946 MW;  42EEB0EAA38BD717 CRC64;
     MSQQRILPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEEEHQVSR STQGEQDNYE
     MHVRSANIVR AGESLMKLVS DLKQFLILND FPSVNESINQ RNQQLRTLRE ECDKKLIALR
     DDIAIDLYEL EEEYYSSSYS VCDPSDLPLC EVYWNRESTA SSPEDLSVPL APIMAEASTV
     TSQIHTPPHL NGHGAGMTEH T