ID   MED23_AEDAE             Reviewed;        1409 AA.
AC   Q16HH9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 23;
DE   AltName: Full=Mediator complex subunit 23;
GN   Name=MED23; ORFNames=AAEL014021;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 23 family.
CC       {ECO:0000305}.
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DR   EMBL; CH478169; EAT33704.1; -; Genomic_DNA.
DR   RefSeq; XP_001664240.1; XM_001664190.1.
DR   AlphaFoldDB; Q16HH9; -.
DR   SMR; Q16HH9; -.
DR   STRING; 7159.AAEL014021-PA; -.
DR   PRIDE; Q16HH9; -.
DR   GeneID; 5579145; -.
DR   KEGG; aag:5579145; -.
DR   VEuPathDB; VectorBase:AAEL014021; -.
DR   eggNOG; KOG1883; Eukaryota.
DR   HOGENOM; CLU_002773_0_0_1; -.
DR   InParanoid; Q16HH9; -.
DR   OMA; HALYVTC; -.
DR   OrthoDB; 94121at2759; -.
DR   PhylomeDB; Q16HH9; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021629; Mediator_Med23.
DR   PANTHER; PTHR12691; PTHR12691; 1.
DR   Pfam; PF11573; Med23; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1409
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   23"
FT                   /id="PRO_0000305936"
FT   REGION          1359..1409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1409 AA;  160831 MW;  175482412F147BB0 CRC64;
     MSTDTQIIKL VEEILCEKTN DYDYEGPMPD EAELQKRAED GMKKFATVFA GMSQEVKENA
     LRSCLIHVAG INHRNKVRKH MQVLKDLVGK GIIPARLLCE QIMSSEKLVY QNQSFWIECF
     QVVRRVIGGV DYKGVREIMK CCKEKALSFP SGISSSILPQ MLELTEVIEH IFNRNACLLP
     AYFIINEIQK ADYQDTHWRI ANLIANFIEE FVIVAQMLSI IGHSSMLPIV EHSSYADNLI
     NPWKLDPTTL KLALRGNLPY EPELLQPQIK LLRFVLEQPY SRDMVCSMLN LQKTQKQKCM
     ALEEQLVWLV MCAMECSEKE PVHTVDGEIS SHTQWVWLHL SSQLIYFVLF QFATFQNIVN
     TLHDKLAVSN LRRGRDHLMW VLLQYISGSI QRNSITNFLP ILKLYDSLYP EKEPLPVPDY
     NNPLCTHQMA PTCIWIHLLK RAQSEHYNIN RSIPTALKLH HEFLQHLVMP NNNATLCMGS
     DYRLALLCNA YSTNPDYFSR PMAALIETIL GNCKNPSAGG GSTSATQPLP TVPLSMSVLD
     SLTIHSKMSL IHSIVTHMIK QAQSKTTVPN TNNMAPALVE TYSRLLVYTE IESLGIKGFL
     GQLLPQVFKS AAWGILYTLL EMFSYRMHHI QPHYRVQLLS HLHSLASVPH TNQMQLHSCV
     ESTALRLITG LGSVEVQAQM SRYVTEQKAP GNIVSAESEE LNRALILTLA RSMQITGTGN
     DPQSTTWCKE LLNSIMQNTP HTWSQHTLQC FPPVLNDLVV QHNVPKENKQ LLKKSVDEEY
     RNWTSMSNEN DIIGHFGTAG TPGTPPLFLC LLFKMIVETD TISPVAYKIL ERIGARALSA
     HLRKLCDYLV FEVSNSGDGA HVNKCVDTIN DMIWKYNIIT IDRLVLCLSL RTLEGNEAQV
     SFCIIQLLLL KTSEFRNRLQ EFVSINSPEH WKQNNWHERH LAFHQKFPEK FTPDESVSHP
     SLPVYFGNVC LRFLPVLDIT IHRYLEVPAA MSKTLDVLLD HLGPLYKFHD RPITYLYNTL
     HYYERMLRDR PQLKKRLVGT VIGSLKDVRP DNWAVTEQYQ SYMSKKDDAV NWMPDLNYYI
     YLVRRMQDTI DGTNIFPGTD WRFNEFPNPP AHALYVTCVE LLGLPVGPQG VANSLIDVVV
     KGYPVIPSQS VHNWINTIGL IMAALPESYW GVIYERLREV ISCPQMTDWL HRQSPFELFN
     FKIVREAMLE KNYVVILAIA QSILHHSGIG QISTVTEHIK ENFKPIIKTE YQLIYLCHLV
     GPFLNRLCAE RSRAVSDITL ILYELLEQVD KAQPSLALKY MDPICDLLYH IKYMFIGDMM
     KSDLEAIIRR LRPALQMRLR FITRLNVDEI GVDQQNVDAS AAGQGPAQGG PQSQQPQTTG
     QAGGQPSVPQ QQQQTQQQQP QQQQQVQQQ