ID   MED23_CAEBR             Reviewed;        1589 AA.
AC   Q60UZ5; A8XWD7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 3.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 23;
DE   AltName: Full=Mediator complex subunit 23;
DE   AltName: Full=Mediator complex subunit sur-2;
GN   Name=sur-2; Synonyms=mdt-23; ORFNames=CBG19759;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 23 family.
CC       {ECO:0000305}.
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DR   EMBL; HE601474; CAP36956.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q60UZ5; -.
DR   SMR; Q60UZ5; -.
DR   STRING; 6238.CBG19759; -.
DR   WormBase; CBG19759; CBP39058; WBGene00038926; Cbr-sur-2.
DR   eggNOG; KOG1883; Eukaryota.
DR   HOGENOM; CLU_244777_0_0_1; -.
DR   InParanoid; Q60UZ5; -.
DR   OMA; HALYVTC; -.
DR   OrthoDB; 94121at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR021629; Mediator_Med23.
DR   PANTHER; PTHR12691; PTHR12691; 1.
DR   Pfam; PF11573; Med23; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1589
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   23"
FT                   /id="PRO_0000305935"
FT   REGION          1381..1499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1390..1426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1448..1474
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1589 AA;  184984 MW;  B3B8CC762E1AC62E CRC64;
     MTEKDKAPNP EDVIEMDDSF SPQFVQEVNR VKSQIKSLIE NNTTLRFFKP LTSNLGDVTA
     ILRISFNNMM SKMEEKEKQS LVKELIKLVH HVAEKNTQDK VFIAASYERV VDELLRYANQ
     KEVISTTLCV EGLIMTSDFR MCSRIDQEKW KFIKECIPKI DYKGIRTIIR YILESQLRRL
     PYQLSPEKVN ELRRVEDVLL KIVDRDLNLM PPLITLSEVM RGTPKQAHMF PRLTEKLANL
     SSHFRPIADL THVCGRPFIY PIPFHPAFHP PTSYWEDFGM NAQSPYTQSH HMLPYRPQHK
     AASCLYTFYM ILRQPLGKDS LNPTNRNKTK SHWEPLLSVM IVEAMAETEA LPEGKQIPRY
     QWDNITNLVM YGMSHLLVNP KNFFHYLKGL INQCKYTRAR DEVMWIVFQV VSSLHKMIKI
     EDAVQEIVDL YNELFDGEFS WHGASDHPAR MARFLAAAST WMLLEKNKAH KQNTDTIKSH
     IKVIHEAALN FDPKNMGMLA VLANAFKSDT RIGAQIVPAM SEALNTPPDP SQPTFDLSYQ
     RKAVNQFDAF PKEFLDALTS RAKRSLLGQI LSVFRSFGTD KLPSPAAFET LARICQSEDY
     EMAVKDLESL ASRSLHISTQ ERAADIATNN QAKDQCHFLF DFLAYRLPHV HSYGKYTSTT
     GSLLLYFTAS VAPNTPQNHQ VYRLLEQALL RRMYWRTFHE SVINHSQLFG SSYKENSNNV
     MLRHLKNPKT FSTPVDQWQF PLNPEIFKMT IYAFMRALKI TGQEIPLDGT MHPIHVAGYG
     WPEKSTTFFP KWALEEIKKT DVKKLAPNYA EILSTTDEAF RMNTLLTGGQ YVIRYADDPN
     PITYHCMLAV IFKQLCSKPE QDLTSEYYQV MEKKSPKDIV VMGNYLVDFI IADVKNNQDC
     NEQTFKTIAK TAALMCFHFN IHRADRFLLS LIMHPSTDED AQICIQIANE FLLTPKFQER
     IKWFYENDVP RKEKDPYEYI KAIVKYHDAF PEFEACQLVP KNDDTGTNVH MPTYYGCLIE
     RLLPILDQYV YVALEQQGYK MSNALLQLVS MFYRYHPMPI HFMYSVLFVS HGKMAGPDAK
     SFVSAFASQI EECHLTEEFE KYNHQKSSCE ELIMELLDRM AASLDFVLTP PTFVAKDWRT
     AEMSPGAQAL YLACIELMAS PHSPEKLVNA MINVMQMRPH LRPFNVFNLI ALLLTALPST
     YADALHEEFI GVFKNGETAN LKFEEIVFDN YDSSLLLHLP NRARSINMIA QIYWTQCNMA
     LLNPFANDQV PKLLEHVKTE KDLWYTLRLV MPIIRRFWDS WDFAKTMRAL RERFGPLVIM
     KLIIEKLGSM AESGVEIVHE APFCDLFYNC KYVFVGDFLR ETAITEFAKL PEAMRERLKY
     YVSQNEPAPP ETPEREKTPE RKDQQKEQQE QQHQQHHQNP QLHHEAQHHP HHPHQQPSMP
     PPQLIPQHHL QHHQQQLHHQ QQQQQHLSQM MPPPQQPLQH LPHHQMDMAP PTPAPMHHQQ
     HQMAMHQQMY PGQMFHHPQG GHMGYGMQHH MQQPHPHHPQ MQGQMPSQMQ HMVRMHNMTP
     QQQQQYAYMM QQQQHHYMQQ QQHQQHHHM