MED23_DICDI
ID MED23_DICDI Reviewed; 1662 AA.
AC Q55BN0;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Putative mediator of RNA polymerase II transcription subunit 23;
DE AltName: Full=Putative mediator complex subunit 23;
GN Name=med23; ORFNames=DDB_G0270434;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=18515835; DOI=10.1093/nar/gkn349;
RA Bourbon H.-M.;
RT "Comparative genomics supports a deep evolutionary origin for the large,
RT four-module transcriptional mediator complex.";
RL Nucleic Acids Res. 36:3993-4008(2008).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 23 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72567.1; -; Genomic_DNA.
DR RefSeq; XP_646801.1; XM_641709.1.
DR AlphaFoldDB; Q55BN0; -.
DR STRING; 44689.DDB0266935; -.
DR PaxDb; Q55BN0; -.
DR EnsemblProtists; EAL72567; EAL72567; DDB_G0270434.
DR GeneID; 8617774; -.
DR KEGG; ddi:DDB_G0270434; -.
DR dictyBase; DDB_G0270434; med23.
DR eggNOG; KOG1883; Eukaryota.
DR HOGENOM; CLU_242121_0_0_1; -.
DR InParanoid; Q55BN0; -.
DR OMA; PIMKNQY; -.
DR PRO; PR:Q55BN0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR InterPro; IPR021629; Mediator_Med23.
DR PANTHER; PTHR12691; PTHR12691; 1.
DR Pfam; PF11573; Med23; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..1662
FT /note="Putative mediator of RNA polymerase II transcription
FT subunit 23"
FT /id="PRO_0000388660"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..122
FT /evidence="ECO:0000255"
FT COMPBIAS 1532..1563
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1662 AA; 193227 MW; 438905AD0DB40695 CRC64;
MYTNIPQQQQ NIPQQQQQNI PQQQNVQNIQ QPLPHTNIQQ QNIQQQQQQY QLQFQKQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQQQRPQT PQQNAQQQSQ QSQQSQQQQA
SLGQGQQGSG PNTPPQSQPE TIESIFKQLD LNSTGQQAKD ILEQCKLKIH SLESQQLIAQ
AKYKLFSLAA NYQSTVFQHI KMVSTTTTPT STPTTSTTNT PQNSNTSSSS STGTSSSTIG
SSSSSTTTST TNNENLGLPI SKEIYQQKIQ LWISIITFLR ENLQYFGKWR ESIYISIQNI
TQSTLLPTLI QKEFFTELFI LLKSIFSFVN IEFPHYIALK EVKLSNTHQC LEYQNLIEPY
YCRAAKLSSL LSLSSLSSSA RIVGSSILLN QDAMIGYTNQ LTESPPFFTS NRLLNNKYST
IVHHLLSQSA SIEPIKELLF PQVQSNTLKS KIISIITEAT ISKTMQLLNK YPNQIIENQI
ENNSWKEWLL FSEQFYFLCE NGLVDLEQFI VTLSEKRMNN GDPIKDNMVV LLISKTIIIQ
DVKTLFKQHL QNVNSNHYGH LIPLVLSFVN NDSNYPIISQ NISLYFFLMR INTNTENPEI
IAHIKKLLDN FNFQFTLFQQ YRNWWESEKV KQKPEFFTTI QDITYFSIIC NVIPTEGEME
LIRFQSNGSD QSIQFPGVGG IGTVVTGKIK PVSNLILLNL SLRCRRKLIQ ESVLLLLDKE
VPISPGFLED YCRTVHYTPG PVSPFLFSYF KKFHRLAPIH AVIESVSHRL LKVLKSNKEL
AVLLRALQDI QTQKPIQNIQ LSRSIDYLLL KASISLPVDL ISAKEIWKSL DLGLFNNRRL
ITSIARLIKL KGIQDFNRIS DVPVFIENCF KSNPYCFSKS TLEFFPDILK NEFKKNSENL
SLNPNQFTNL TLMKPPTLQK VQLENQQRFQ LFSVGGKLQI LQKQALVQQY LTDNNSNLLL
CQVFIYMLEN KIKMDVMGPL IQQMFFKQII GNQQPQQQQQ PQQPPPLAIS NQQLNRITSV
FIDFIFDEVY VNHPLKQENL HQHVSEFLCQ SIFTYKILTL NSVLLALLDR DDHPSMPTIL
DTFLFSSAEI QNRLQFFSTY PSDFFISQSF RNDDNYFIKN CEFNNRFNDL IPTVIDPNTL
IEQSTQDTIL PIYYSNSISR LMPIVEIIIS KSIELNNGDL FEKTINHFNI PYHYYQDEKE
TTIKDTLIYY YDSQLFKLNP ELKLLFLKLL NQSDIDNRFS NIFNQFLKSS RIEDITMVGS
TAYFNDLISP LAEMMDLTNQ NVFDTFSFKT ENTFSSIDIS NPLELKLNNI ILEILLLPLD
SNWIANGLVS LLNYSNRNKN FSDRKIDPPS SSMVLALSII FSILPTQIHN SFIPIVTQNL
SNELNFSKFK SPIMKNQYNF GNYTTNVEEK MTEPIEWYIY FIQFYYLYCP LERLLSLNDL
VTNIRPLIKN VYQYYVLLTI VSPVLLRFGT QTNHLIQITR EMLQILTDSY LSSYIENTLQ
DLESCWIGNT NDDDDIMDTT NFNLFGKRIG YDDDDDDEDD DYYDEDDEDE DDDNEDDQQD
ENDRMDFSQD TNNIFNRSMG DHDHLMMMSN SENLNDPWSD KNEFFRKQKS IFLKIDSQLI
DTIIDWIYHI KMIFPFQPFR DELLRIVKEF KPNFLSKFNQ LN
