ID   ARH37_RAT               Reviewed;         676 AA.
AC   A1IGU3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Rho guanine nucleotide exchange factor 37;
DE   AltName: Full=Protein 2-88;
DE   AltName: Full=Scaffold protein tuba 3;
GN   Name=Arhgef37;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RA   Yamazaki N.;
RT   "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and
RT   human.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a guanine nucleotide exchange factor (GEF).
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB199794; BAF43708.1; -; mRNA.
DR   RefSeq; NP_001094444.1; NM_001100974.1.
DR   AlphaFoldDB; A1IGU3; -.
DR   SMR; A1IGU3; -.
DR   STRING; 10116.ENSRNOP00000037964; -.
DR   PhosphoSitePlus; A1IGU3; -.
DR   PaxDb; A1IGU3; -.
DR   PeptideAtlas; A1IGU3; -.
DR   PRIDE; A1IGU3; -.
DR   GeneID; 307398; -.
DR   KEGG; rno:307398; -.
DR   UCSC; RGD:1560471; rat.
DR   CTD; 389337; -.
DR   RGD; 1560471; Arhgef37.
DR   eggNOG; KOG3519; Eukaryota.
DR   InParanoid; A1IGU3; -.
DR   OrthoDB; 207472at2759; -.
DR   PhylomeDB; A1IGU3; -.
DR   Reactome; R-RNO-193648; NRAGE signals death through JNK.
DR   Reactome; R-RNO-416482; G alpha (12/13) signalling events.
DR   PRO; PR:A1IGU3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR   CDD; cd11941; SH3_ARHGEF37_C2; 1.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR035636; ARHGEF37_SH3_2.
DR   InterPro; IPR035823; ARHGEF37_SH3_C1.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 2.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome; Repeat;
KW   SH3 domain.
FT   CHAIN           1..676
FT                   /note="Rho guanine nucleotide exchange factor 37"
FT                   /id="PRO_0000337052"
FT   DOMAIN          30..213
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          254..455
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   DOMAIN          506..569
FT                   /note="SH3 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          603..666
FT                   /note="SH3 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  76407 MW;  9F70CED2B387399D CRC64;
     MADFETDEAS SKSESPEQEG QGSEDKSLLH QRLAIRELID TEVSYLHTLR LCTSDIRGHL
     QQLPPGDLDI LFSNIDDIIQ VSSRFLHGLQ ETACKEEKQA HLIGNLFLEF QEELEQVYKV
     YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAVPQAGPSG LSFLLVIPLQ RITKYPLLLQ
     KILENTPADA SAHPVLQRAT SALQDVNSNI NEYKMRKEVA LKYTKVEQLS LRERLARINT
     HTLSKKTTRL SQLLKQEAGL VPRTEDKEFD DLEERFQWVS LCVTELKSNV AAYMDNLEAF
     LCFRPHERNL DIPGGAAEQY CSLARDLQLQ AFLQFKQRLT GLVWQPLCSL ARALVGPQNL
     IKKRLDKLLD FERVEEKLLD VGSVTYEEEA ARHTYQALNS LIVAELPQFN HLVMQWLGQI
     LRTFVVLQRD LADQVLRRAE SSMALLPHRH VSEPDFQKLL EDTLGQSSSQ LRHFRESFEK
     VLPPSTSQPL LPGSEHQMQS LLTRYGPGKI YQVTSNINGT GTLDLTLPRG QIVALLQNKD
     TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI NPSEKEPRRQ TGMPEDYWLP TPEPTQPSVP
     TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF
     LARTPSPTPR GWNLPS