ID   MED23_XENLA             Reviewed;        1369 AA.
AC   Q6P423;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 23;
DE   AltName: Full=Mediator complex subunit 23;
GN   Name=med23;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 23 family.
CC       {ECO:0000305}.
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DR   EMBL; BC063725; AAH63725.1; -; mRNA.
DR   RefSeq; NP_001083684.1; NM_001090215.1.
DR   AlphaFoldDB; Q6P423; -.
DR   SMR; Q6P423; -.
DR   IntAct; Q6P423; 2.
DR   MINT; Q6P423; -.
DR   GeneID; 399060; -.
DR   KEGG; xla:399060; -.
DR   CTD; 399060; -.
DR   Xenbase; XB-GENE-1003997; med23.L.
DR   OrthoDB; 94121at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 399060; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021629; Mediator_Med23.
DR   PANTHER; PTHR12691; PTHR12691; 1.
DR   Pfam; PF11573; Med23; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1369
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   23"
FT                   /id="PRO_0000305934"
FT   REGION          1337..1369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1339..1359
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1369 AA;  156572 MW;  303EC38E96A56EA2 CRC64;
     MESQLQSIFE EMVKTEIIEE AFAGMFMDTP EDERTKLISC LGAFRQYWSV LPQESHEQCV
     QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRMVCEA LINSDSLEWE RTQLWILTFK
     LIRKIIGGVD YKGVRDLLKV ILEKIQTVPD TVSSAVVQQL LAAREVVAYI LERNACLLPA
     YLAVTEVLKL YPEGKLPHWL LGDLVSDFVD SFRPTARIGS ICGRCSLLPV VNNSGAICNS
     WKLDPLTLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL
     EDQLVDLVVY AMERSETEEK YDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL
     AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKECIP VPDITKPQST
     HSFAMTCIWI HLNRKAQNDN SKLQIPIPHS LKLHHEFLQQ SLRNKSLQMT DYKIALLCNA
     YSTNSECFTL PMGVLVETIY GNGNVNIPLP GSNCMASGSI TPLPMNLLDS LTVHAKMSLI
     HSIATRVIKM AQAKSTFALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI
     LHTLLEMFSY RMHHIQPHYR VQLLSHLHSL AGVPQTNQNQ LHLCVESTAL RLITALGSSE
     VQPQFTRFLS DPKTVLSAES EELNRALILT IARATHVTDF FTGSESIQGT WCKDILQTII
     SFTPHNWALH TLSCFPAPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM TNENDIITHF
     SLQGSPPLFL CLLWKMLLET DQINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG
     QQLNKCIEML NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV
     SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VNPPVQIQPQ YLPIYFGNVC
     LRFLPVFDIV IHRFLELIPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMQLRDRT
     NLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK FGMNPRDDNP WIPDDTYYCK LIGRLVDTMA
     GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVPGK DVGNALLNVV LKSQPLVPRE
     NITAWMNAIG LIITALPEPY WIVLHDRIVN ILNSPSLTSE TEWVGYPFQL FDFTACHKAY
     SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LPEVLIPIVK TEYQLLYVYH LIGPFLQRFQ
     QERTRCMIEI GVAFYEMLLN VDQCSTHLSF MDPVCDFLYH MKYMFTGDSI KDQVEKIICN
     LRPALKLRLR HITHISTESA APPPPPMNSG SPAPQPNQVP VSVPLTVTQ