ID   MED24_AEDAE             Reviewed;        1005 AA.
AC   Q16X15;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 24;
DE   AltName: Full=Mediator complex subunit 24;
GN   Name=MED24; ORFNames=AAEL009027;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 24 family.
CC       {ECO:0000305}.
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DR   EMBL; CH477548; EAT39141.1; -; Genomic_DNA.
DR   RefSeq; XP_001653641.1; XM_001653591.1.
DR   AlphaFoldDB; Q16X15; -.
DR   SMR; Q16X15; -.
DR   STRING; 7159.AAEL009027-PA; -.
DR   GeneID; 5571389; -.
DR   KEGG; aag:5571389; -.
DR   VEuPathDB; VectorBase:AAEL009027; -.
DR   eggNOG; ENOG502QPJD; Eukaryota.
DR   HOGENOM; CLU_007484_0_0_1; -.
DR   InParanoid; Q16X15; -.
DR   OMA; TWQDICL; -.
DR   OrthoDB; 739187at2759; -.
DR   PhylomeDB; Q16X15; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   InterPro; IPR021429; Mediator_Med24.
DR   PANTHER; PTHR12898; PTHR12898; 1.
DR   Pfam; PF11277; Med24_N; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1005
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   24"
FT                   /id="PRO_0000305917"
SQ   SEQUENCE   1005 AA;  113800 MW;  B82C4C58B9750721 CRC64;
     MIMDNQKSTS KTTLLKLMLL RAWKERWTDC QWGINVKAVL TRGVSGDVYN LADCILQQAV
     VGSGANTLFL SYLKHSLCAH LISHAAVLKR ISKYDHFEMH HCLIALLEFL ESIIGGVTCR
     GKQEEGLLTK AMLSLVYWLM QIYEHAIETF SENRSLTTEQ QEVVEKTANV LEKIVQSQFL
     LGVVFVGKFE DPELFGMLAK KCLEIENLTV KSGFVPPVVS QKNVTVNDYI RKVASIETET
     LEIKEFDGKG VEPITYCMQP LIAIDILFNP NCDTQMYVLE FLSIQALKGF PLSRLYCEII
     RACLTCLNNV SGTSRESYIC AFTFIKVPQI MRQIHLQTRV LTPNDFEDAK LDYSPDVVEA
     FELLLQDSAI LDFMDAKCAC NTVEYLLNEM LKHHLINEKY SKLIAAKRDG ITSSLQKLDL
     NTNQHSIVKF VLRAEPPLVG ILKTLSSDYN KVQEALLGML CQVLSGNSFE LILSVATVEG
     KLKTFVAGLI KCNENSKQVP GEMGKPAMTR AALFDVSFLM LVFIVQNYGS EGVLTDGTDS
     FFEKWVRECM VEKHKSKSPM NMVKLCDQNK VDELIVSLNS PDGLKATSLK WQEICANIPG
     LLYQVLLAWE NETLSTGEIK KFLDSLKSRF CCFSICATSW LCAYMQIIRQ DELLKPMNMI
     QQFVTNISSE EMMQQEYLKE RLGLTVQIIR KMQIDFQRLP VASPKMRNQL QSQSLVSQAP
     LEEQFEEVWK GVLEKGWLPI EATLALENLL QSCGPFWLVD KLVQQIFHCK YIREMNKTMD
     IVFAIMHLDI ERCTIALLSQ LVPMMLLNKL QISEIVDPFS RVLAKLCVYC IVATMEAPAV
     PTKKRSRAAI TAEGDELDTL CSTPKMRKIG SESCDSSSSD FMLEQVLAAR DNPAPLKEPL
     QGCLQTLFRT FSQYIVSDEL SPKIFFMFQL LSLLVEVGKD RIKPVLKLIP NGLIQNMMKI
     NATDDMTVGF ILRLYDLNTA SGRQFAMSDL CLFRNIQMRK DSIKL